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CNS 2016
December 05-07, 2016
Volume 7, Issue 5(Suppl) J Neurol Neurophysiol
ISSN: 2155-9562 JNN, an open access journal
conferenceseries .com
December 05-07, 2016 Dubai, UAE
2nd International Conference on
Central Nervous System Disorders & Therapeutics
T Erhan Cosan et al., J Neurol Neurophysiol 2016, 7:5(Suppl)
Elevated hippocampal tau levels at the early stage in experimental subarachnoid hemorrhage
T Erhan Cosan, Turhan Kandemir, Fulya Buge Ergen and Didem T Cosan
Eskişehir Osmangazi University, Turkey
Objective: Subarachnoid hemorrhage is a devastating disease with up to 95% of survivors reporting cognitive impairment and
poor quality of life. Microtubule integrity and thus its role on the neuronal polarity are important in conserving cytoskeletal
structure and function. Tau is well known protein interacting with mostly axonal microtubules. They support the stabilization
of microtubules, inhibition of depolymerization andmicrotubule rigidity. In our study, we investigated hippocampal tau protein
tissue levels in the rats housed in isolated, standard and enriched environment after experimental subarachnoid hemorrhage.
Material & Method: Hippocampal microtubule-associated protein tau (MAPT) levels were determined by enzyme-linked
immunosorbent assay (ELISA) kit (Elabscience) according to the manufacturer’s instructions. Results were obtained at 7th day
and 14th day after subaracnoid hemorrhage.
Results: At first week after subarachnoid hemorrhage, tau levels were increased in the rats housed in isolated and standard
environment, reduced in the rats housed in enriched environment. Two weeks after subarachnoid hemorrhage, tau levels
reduced in all groups.
Conclusion: At the early stage of subarachnoid hemorrhage in the experimental rats, axonal tau proteins to stabilize neuronal
microtubule integrity with standard and isolated environment housing may be more favorable.
Biography
T Erhan Cosan is currently working as a Professor in the Department of Neurosurgery at Eskisehir Osmangazi University (Eskisehir, Turkey). He has published
several original research papers in reputed journals and also participated in several scientific meetings.