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CNS 2016
December 05-07, 2016
Volume 7, Issue 5(Suppl)
J Neurol Neurophysiol
ISSN: 2155-9562 JNN, an open access journal
conferenceseries
.com
December 05-07, 2016 Dubai, UAE
2
nd
International Conference on
Central Nervous System Disorders & Therapeutics
J Neurol Neurophysiol 2016, 7:5(Suppl)
http://dx.doi.org/10.4172/2155-9562.C1.041From discovering calcium paradox to Ca
2+
/cAMP interaction: Impact in human health and disease
Leandro Bueno Bergantin and Afonso Caricati-Neto
UNIFESP-Escola Paulista de Medicina (EPM), Brazil
T
he hypothesis of the so-called calcium paradox phenomenon in the sympathetic neurotransmission has its origin in
experiments done in models of neurotransmission since 1970’s. Historically, calcium paradox originated several clinical
studies reporting that acute and chronic administration of L-type Ca2+ Channel Blockers (CCBs), drugs largely used for
antihypertensive therapy such as verapamil and nifedipine produces reduction in peripheral vascular resistance and arterial
pressure, associated with a paradoxical sympathetic hyperactivity. Despite this sympathetic hyperactivity has been initially
attributed to adjust reflex of arterial pressure, the cellular and molecular mechanisms involved in this paradoxical effect of
the L-type CCBs remained unclear for four decades. Also, experimental studies using isolated tissues richly innervated by
sympathetic nerves showed that neurogenic responses were completely inhibited by L-type CCBs in high concentrations, but
paradoxically potentiated in low concentrations, characterized as a calcium paradox phenomenon. We discovered in 2013
that this paradoxical increase in sympathetic activity produced by L-type CCBs is due to Ca2+/cAMP interaction. Then, the
pharmacological manipulation of this interaction could represent a potential cardiovascular risk for hypertensive patients
due to increase of sympathetic hyperactivity. In contrast, this pharmacological manipulation could be a new therapeutic
strategy for increasing neurotransmission in psychiatric disorders such as depression and producing neuro protection in the
neurodegenerative diseases such as Alzheimer´s and Parkinson´s diseases.
leanbio39@yahoo.com.br