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conferenceseries
.com
Volume 9, Issue 9 (Suppl)
J Cancer Sci Ther, an open access journal
ISSN: 1948-5956
World Cancer 2017
October 19-21, 2017
25
th
WORLD CANCER CONFERENCE
October 19-21, 2017 | Rome, Italy
Relationship with colorectal cancer and microbiota
Esma Oguz, Gül Ögren
and
Fatma Esra Gunes
Marmara University, Turkey
C
olorectal cancer (CRC) is one of the most common types of cancer and the fourth leading cancer deaths all around the
world. Many risk factors such as tobacco and alcohol consumption, over consumption of red and processed meat, age,
physical activity, body weight, diet, inflammatory bowel disease, obesity and diabetes are associated with colorectal cancer.
Another factor in the development of colorectal cancer is microbiota. Microbiota consist of bacteria, viruses, fungi and parasites
that colonize the gastrointestinal tract from the mouth to the colon. Microbiota influences physiological functions from the
maintenance of barrier homeostasis locally to metabolism, haematopoiesis, inflammation, immunity and other functions
systemically. The composition of microbiota is related to various diseases such as cancer, non alcoholic fatty liver disease,
obesity. Studies show that microbiota plays a role in the etiology of various types of cancer by affecting inflammation, DNA
damage and apoptosis. Microbiota has a great influence on immune responses and chronic inflammation is a known risk factor
for colorectal cancer. Colon mucosa is constantly exposed to intestinal microbiota and its metabolites, it has the potential of
continuous low-grade inflammation with bacterial stimulation of immune responses. Gut dysbiosis is largely associated with
direct hostility to colonic cancer or metabolic change. Studies show that various bacterial species include the pathogenesis
of CRC. Functional different bacterial species are involved in tumor microbiology during tumorigenesis. For example, some
potential pro-oncogenic pathogens such as enterotoxigenic B. Fragilis and Escherichia-Shigella may induce tumor formation.
The tumor cells are located in the nucleus of the immune cells, which serve both the pro- and antitumor immunity and can be
shaped by the resident microbiota even after progression to the CRC. Microbiota, immune system, and CRC are multifactorial
associations that should deeply consider.
Biography
Esma Oguz has completed his/her Bachelor of Nutrition and Dietetic from Yeditepe University and is currently enrolled in the master’s programme at the Departmant
of Nutrition and Dietetic, Marmara University. He/She is also Research Assistant at the same university.
esmaoguz34@gmail.comEsma Oguz et al., J Cancer Sci Ther 2017, 9:9(Suppl)
DOI: 10.4172/1948-5956-C1-112