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conferenceseries
.com
Volume 9, Issue 9 (Suppl)
J Cancer Sci Ther, an open access journal
ISSN: 1948-5956
World Cancer 2017
October 19-21, 2017
25
th
WORLD CANCER CONFERENCE
October 19-21, 2017 | Rome, Italy
Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway
Caiyun Zhong
1
, Yue Chen
1
, Jianyun Zhu
1
, Yuan Li
1
, Xiaoqian Wang
1
, Yu Meng
1
, Chunfeng Xie
1
, Xiaoting Li
1
and
Hongyu Han
2
1
Nanjing Medical University, China
2
Sun Yat-sen University Cancer Center, China
C
ancer stem cells (CSCs) play a crucial role in the process of cancer development. Targeting CSCs may be an effective
way for adjuvant therapy to prevent the progression of cancer and prolong life. Phenethyl isothiocyanate (PEITC), the
major active component from cruciferous vegetables, exhibits inspiring interventional effects in various human cancers.
However, the effects of PEITC on colorectal CSCs and the underlying mechanisms remain unclear. The present study examined
the inhibitory effects of PEITC on CSC-like properties in colorectal cancer spheroids. We revealed that PEITC inhibited
the spheroid formation capacity of colorectal cancer cells as well as the expression of colorectal CSCs markers, along with
suppression of cell proliferation and induction of apoptosis. Moreover, we illustrated that PEITC down-regulated the activation
of Wnt/β-catenin pathway, whereas up-regulation of Wnt/β-catenin diminished the inhibitory effects of PEITC on colorectal
CSCs. Taken together, this study suggests that PEITC can be an effective natural compound targeting colorectal CSCs through
suppression of Wnt/β-catenin pathway, and thus may be a promising agent for colorectal cancer intervention.
Biography
Caiyun Zhong has completed his PhD from University of California, Davis, USA in 2005 and received Diplomate of the American Board of Toxicology (DABT) in
2010. He is the Director and Professor of the Department of Nutrition and Food Safety, School of Public Health, Nanjing Medical University. He has published more
than 40 papers in reputed journals and has been serving as an Editorial Board Member of journals.
cyzhong@njmu.edu.cnCaiyun Zhong et al., J Cancer Sci Ther 2017, 9:9(Suppl)
DOI: 10.4172/1948-5956-C1-112