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Volume 7, Issue 6 (Suppl)
J Biotechnol Biomater, an open access journal
ISSN: 2155-952X
World Biotechnology 2017
December 04-05, 2017
2
nd
World Biotechnology Congress
December 04-05, 2017 | Sao Paulo, Brazil
Activity of derived extracts from
Annona coriacea Mart
. on head and neck tumor lines
Aline T M Coelho
1
, Rodolfo E M Ribeiro
1
, Ana G Silva
1
, Gilvânia A R Cordeiro
1
, João G M Junqueira
2
, Vanessa G P Severino
2
, Renato J S Oliveira
3
, Rui M V
Reis
3
and
Rosy I M A Ribeiro
1
1
UFSJ, Brazil
2
UFG, Brazil
3
HCB-CPOM, Brazil
H
ead and neck squamous cell carcinoma (HNSCC) makes up about 90% of head and neck neoplasms. The treatment is aggressive,
the 5-year survival rate is around 50-60% and the local recurrence is 20-30%. Studies report that the use of new antitumor drugs
of natural origin, besides efficient, offers a wide field for new research. So the objective of this work is to identify the antineoplastic
potential of seven extracts of the species
Annona coriacea Mart
. on head and neck tumor lines. In the cell viability assay, only the
compound C4 did not reach representative IC50 values on the tested lines (HN13 and FaDu). Of the seven compounds, four (C1,
C2, C3, and C5) exhibited better results and were selected to follow in further assays. In the cell migration assay, it was seen that the
C2, C3, and C5 compounds inhibited the migration in HN13 and C3 and C5 in FaDu, above all in 48 hours after treatment. Changes
in cell morphology were observed in the lines, which after treated with the compounds in the time of 48 hours showed cytoplasmic
projections and vacuoles (HN13) and higher nuclear condensation (FaDu) compared to the control (Images 3 and 4). The results of
this study contribute to the development of new antineoplastics that may help the treatment of HNSCC improving the prognosis and
leading to cure.
Biography
Aline T M Coelho is a Biochemistry student at Federal University of São João del-Rei, Campus Centro-Oeste Dona Lindu (UFSJ-CCO), Technician in Pharmacy by the
institution Conceição Ferreira Nunes, Divinópolis/Mg and student of scientific initiation in the Laboratory of Experimental Pathology (Lapatex), UFSJ-CCO.
coelhoalinem@gmail.comAline T M Coelho et al., J Biotechnol Biomater 2017, 7:6 (Suppl)
DOI: 10.4172/2155-952X-C1-085