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Volume10, Issue 12 (Suppl)
J Proteomics Bioinform, an open access journal
ISSN: 0974-276X
Page 102
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World Biomarkers & Pharma Biotech 2017
December 07-09, 2017
December 07-09, 2017 | Madrid, Spain
&
20
th
International Conference on
PHARMACEUTICAL BIOTECHNOLOGY
9
th
WORLD BIOMARKERS CONGRESS
JOINT EVENT ON
J Proteomics Bioinform 2017, 10:12(Suppl)
DOI: 10.4172/0974-276X-C1-110
Acetylcholinesterase inhibiting activity of compounds isolated from
bauhinia rufescens
Aminu Muhammad
1
and
Hasnah Mohd Sirat
2
1
Bayero University Kano, Nigeria
2
Universiti Teknologi Malaysia, Malaysia
T
his study has tested the
in vitro
anti-acetylcholinesterase activity of compounds isolated from the stem bark of
Bauhinia rufescens
by employing TLC bioautographic and Ellman’s spectrophotometric methods. Among the compounds oxepin (IC50, 516.63 μM),
seqouyitol (IC50, 463.77 μM) and α-amyrin acetate (IC50, 832.80 μM) which exhibited a significant acetylcholinesterase inhibitory
activity in comparison with a positive control, the galantamine hydrobromide (IC50, 2.92 μM). The phytochemicals isolated from the
stem bark of B. rufescens had demonstrated a potent anti-cholinesterase inhibition.
amuhammad.chm@buk.edu.ng