Notes:
Volume10, Issue 12 (Suppl)
J Proteomics Bioinform, an open access journal
ISSN: 0974-276X
Page 97
conferenceseries
.com
World Biomarkers & Pharma Biotech 2017
December 07-09, 2017
December 07-09, 2017 | Madrid, Spain
&
20
th
International Conference on
PHARMACEUTICAL BIOTECHNOLOGY
9
th
WORLD BIOMARKERS CONGRESS
JOINT EVENT ON
Combination of Pulsatile and Sustained Effects in Multi-Layer Tablet
Kirolos Raafat
1
, Ragwa M Farid
2
, Ehab R Bendas
3
and
Randa Latif
4
1 B.Sc.ofpharmaceutical sciences, Faculty f Pharmacy & Drug Manufacturing, Pharos Unieristy in Alexandria, Egypt
2
Assoc. Prof. of pharmaceutics, Faculty of Pharmacy & Drug Manufacturing, Pharos Unieristy in Alexandria, Egypt
3
Prof. of pharmaceutics,Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University in Egypt, Egypt
4
Assoc. Prof. of pharmaceutics, Faculty of pharmacy, Cairo Univeristy, Egypt
T
he main objective of the present study is to formulate and evaluate a multi-layer pulsatile drug delivery system (MPDDS)
for time dependent release. Based on the utilization of different types of polymers in different ratios. The MPDDS was
designed to deliver a rapid pulse of drug after a lag time when it is most needed to patients and another quantity of drug
delivered over prolonged period for maintenance dose. The model drug, Etodolac, was incorporated in two separate layers.
Sodium starch glycolate (SSG) polymer was incorporated in the fast release (FR) layer. Eudragit RSPO and HPMC K15M
polymers were blended with the drug in the sustained release (SR) layer. The two layers were compressed into bilayer tablet
using a single-punch tablet machine. Three successive polymer layers of OpadryII, HPMC E5/K4M and Surelease were spray
coated using a conventional pan coating processes to provide a lag time before drug release. Bilayer tablets were evaluated for
pre- and post-compression parameters. Tablet optimization was performed based on in-vitro dissolution behavior. Addition
of 6.67% SSG polymer in the FR layer showed 85.02±0.50% release in 10 min, which is beneficial in the manufacture of fast
and pulsatile release tablets. Polymer mixture of Eudragit RSPO and HPMC K15M (2.5:1) resulted in 72.44±0.44% in 12 hours
which directly influence the prolongation of drug release. Accession of HPMC K4M to that of E5 (1:80) lengthens the lag time
from 2 to 4 hours. Bilayer tablets of etodolac were successfully formulated which achieved a desirable lag time followed by
controlled drug release.
Biography
Kirolos Raafat is researching in the field of modified drug delivery systerms. He started his studies testing different techniques of drug delivery, then currently he
is trying the combination of multiple techniques to reach optimized techniques for various drugs. He is currently working in medical healthcare institution and he is
working on the enhancement of the clinical pharmacy practice in Egypt. He is targeting to enter the field of long-term treatment modification in his next researches.
Kirolos.r.g@gmail.comKirolos Raafat et al., J Proteomics Bioinform 2017, 10:12(Suppl)
DOI: 10.4172/0974-276X-C1-110