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Volume 4
Toxicology: Open Access
ISSN: 2476-2067
Toxicology Congress 2018
March 12-14, 2018
March 12-14, 2018 Singapore
14
th
World Congress on
Toxicology and Pharmacology
Hepatoprotective effect of
Phyllanthus niruri
against the Paracetamol induced liver toxicity in albino rat
Akshath S U, Vijaya Kumar and Sankaran
Saveetha Medical College and Hospital, India
T
o investigate the mode of action of
Phyllanthus niruri
as a prophylactic hepato-protective agent against Paracetamol (PCM)
induced liver toxicity in albino rats. Five groups of six animals in each group of Wistar rats with a weight of 180-210 gm
were the experimental material. Group-I was served as normal control, administered sodium CMC for all the eight days.
Group-II rats were treated only with PCM at a dose of 2.5 gm/kg on 8
th
day. Group-III animals were administered silymarin at a
dose of 50 mg/kg for eight days and PCM at a dose of 2.5 gm/kg on 8
th
day, while Group-IV is the treated group which was given
P. niruri
aqueous extract at a dose of 200 mg/kg followed by PCM of 2.5 gm/kg on 8
th
day. Group-V rats were administered with
P. niruri
at a dose of 400 mg/kg for 8 days and PCM at a dose of 2.5 gm/kg on 8
th
day. Biochemical, histological and immune-
histological (IHC) examinations were performed. Histo-pathological picture is in line with the biochemical parameters and
IHC study revealed that
P. niruri
acts by preventing the increase in NKT cells subsequently blocking FASL, by anti-apoptotic
and by increasing regeneration.
Phyllanthus niruri
aqueous extract at a dose of 400 mg/kg was more effective than at 200 mg
and silymarin 100 mg.
Biography
Akshath S U is currently pursuing his MBBS from Saveetha Medical College, SIMATS. His research is on the hepato-protective effect of
Phyllanthus niruri
against
the Paracetamol induced liver toxicity in albino rats under the mentorship of Dr. Sankaran, Department of Anatomy, SIMATS in India.
akshath.s.u@gmail.comAkshath S U et al., Toxicol Open Access 2018, Volume 4
DOI: 10.4172/2476-2067-C1-005