26 / 32
Page 62
Notes:
conferenceseries
.com
Volume 4
Toxicology: Open Access
ISSN: 2476-2067
Toxicology Congress 2018
March 12-14, 2018
March 12-14, 2018 Singapore
14
th
World Congress on
Toxicology and Pharmacology
All is not well: Irrational nutraceutical zinc preparations in Indian scenario, a systemic analysis
Rithu Baskaran and V Krishnan
Saveetha Medical College and Hospital, India
Introduction & Scope:
In a report of by World Health Organization in 2003, detailed description of morbidity and mortality
prevention of diarrheal illness among children by effectiveness of zinc is provided. Role of zinc in diarrheal illness when
used approximately is evident by other pharmaco-epidemiologic studies as well. However, zinc should be administered as
per dosage recommendation given vide infra in discussion and should be curtailed in adding with other nutraceuticals which
is neither effective nor safe as zinc has its own adverse effects. Hence this observational study was conducted to analyze the
currently available rational and essential zinc formulation in our country.
Objective:
To critically analyze the essentiality and irrational zinc preparations available in Indian markets.
Methods:
This was conducted as cross-sectional analysis by department of pharmacology of our tertiary care hospital between
June and December 2016. Data regarding various formulations of zinc were retrieved from current index of medical sciences
and drug India database. Rationality assessment was done using prescribed guidelines and approved formulations of zinc by
central drug standard control organization. Essentiality was checked using national list of essential medicine India, 2013 and
latest version of WHO list essential medicine bulletin. Dosage regulation was assessed using Indian pharmacopeia guidelines,
National Institute of Nutrition, India recommendation and upper daily intake toxicity intake, United States of America (USA).
Results:
Our study results showed wide variation in the number of zinc preparation. Total number of formulation available
in the market is 335. Among zinc preparation, the preparation that contains 20 mg of zinc as recommended by various
guidelines is 10 in number. About 325 preparations of zinc are added with one or more nutraceuticals. None of these fixed dose
combinations of zinc containing preparation is recommended as essential fixed regimen.
Conclusion:
Zinc has lot of relevance in treating recurrent diarrheal illness, especially in pediatric cases, however legal,
regulatory and educational measures should be followed to curtail all the irrational zinc prescription development, promotion,
marketing and prescription.
Biography
Rithu Baskaran is currently pursuing her MBBS from Saveetha Medical College, SIMATS. Her area of research is drug development, under the mentorship of Dr.
V Krishnan, Department of Pharmacology, SIMATS in India.
rithubaskaran@gmail.comRithu Baskaran et al., Toxicol Open Access 2018, Volume 4
DOI: 10.4172/2476-2067-C1-005