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Volume 4 Toxicology: Open Access
ISSN: 2476-2067 Toxicology Congress 2018
March 12-14, 2018
March 12-14, 2018 Singapore
14th World Congress on
Toxicology and Pharmacology
Localization of glial fibrillary acidic protein in rat migraine model Wistar rats
Bryan Joel Devaraj, P K Sankaran and Yuvaraj
Saveetha Medical College and Hospital, India
Purpose: The trigeminal ganglion consists of pseudo-unipolar neurons surrounded by satellite glial cells and processes
innervating craniofacial region. The gap junctions are trans-membrane proteins formed between the cell membranes of
adjacent cells and calcitonin gene related peptide are neuropeptides secreted by sensory neurons. Glial cells which surround
the pseudo unipolar neurons directly modulate neuronal function and activity by changing the ionic concentrations in and
around the neurons.
Methodology: The rats were divided into two groups: Group-1 (n=6): control rats, Group-2 (n=6): Nitroglycerine treated rats
6 mg/kg. Then immune-histochemical localization of glial fibrillary acidic protein in trigeminal ganglion was done in both
groups after standardizing dilution ratio.
Findings & Conclusion: GFAP was present in satellite glial cells surrounding the neuron and in the nerve fibers in control
rats. In migraine model rats there was increased intensity of GFAP in the satellite glial cells and nerve fibers indicating its role
in allodynia. Up-regulation of GFAP in painful conditions like migraine and neuralgic conditions may be an important factor
in activating surrounding neurons by releasing interleukins and TNF from the satellite glial cells. The antagonist to GFAP can
block the inflammatory cascade and can be used in the treatment of migraine.
Biography
Bryan Joel Devaraj is currently pursuing his MBBS from Saveetha Medical College, SIMATS. His area of research is drug development under the mentorship of Dr.
Sankaran, Department of Anatomy, SIMATS in India.
Bryan Joel Devaraj et al., Toxicol Open Access 2018, Volume 4
DOI: 10.4172/2476-2067-C1-005