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19th International Conference on
Obesity, Healthcare - Nutrition & Fitness
March 18 - 19, 2019 | New York, USA
GC-MS and molecular
docking studies for
identification of anti-
diabetic compounds
in methanolic extract
of hunteria umbellata
seeds
Olusola Abiola Ladokun
Lead City University, Nigeria
T he purpose of this
study was to investigate
the diabetic effect of
phytocompounds synthesized
from Hunteria umbellata using
GC-MS analysis and molecular
docking studies. Peroxisome
proliferator-activated receptor
gamma (PPAR-γ) agonists are
beneficial in the treatment of
diabetes by stimulating insulin
sensitivity and antagonizing
hepatic gluconeogenesis. The
aim of the present study was
to investigate PPAR-γ agonist
property of phytocompounds
from Hunteria umbellata
using in-silico approach.
Molecular docking of Hunteria
umbellata on human PPAR-γ
protein was determined by
Auto/Vina in Pymol 4.2 and
compared with Gilbenclamide,
a known agonist of PPAR-γ.
Our present study reports
the phytochemical analysis of
the extracts of the seeds and
leaves of Hunteria umbellata.
21 compounds were revealed
through GC-MS analysis and
screened using Autodock/
Vina against PPAR-γ. Docking
studies recommended
that 2,2-Benzylidenebis
(3-methylbenzofuran) an
existing phytochemical
from the seed of Hunteria
umbellata had the highest
fitness score of-11.3 Kcal/mol
and hence could be a potent
antidiabetic drug. Hunteria
umbellata seed extract and its
compound 2,2-Benzylidenebis
(3-methylbenzofuran) have a
significant antidiabetic activity
against PPAR-γ. Molecular
binding interaction of an
in-silico data demonstrated
that 2,2-Benzylidenebis
(3-methylbenzofuran) has
more specificity towards
the PPAR-γ binding site and
could be a potent antidiabetic
compound.
Biography
Olusola Abiola Ladokun is
a Professor of Nutritional
Biochemistry in the
Department of Biochemistry,
Faculty of Sciences, Lead
City University, Ibadan. She
holds a PhD in Agricultural
Biochemistry and Nutrition
from the University of Ibadan,
Ibadan, Nigeria. She is the
current serving Dean of the
Faculty of Basic Medical and
Applied Sciences. She has to
her credit several articles in
both local and international
journals, chapters in books and
conference proceedings. Her
areas of research include but
not limited to Food Chemistry,
Ethnopharmacology, and
Functional Foods. She has
attended and presented papers
in conferences and workshops
in Nigeria and Internationally.
SCIENTIFIC TRACKS | DAY 2 JOURNAL OF OBESITY &WEIGHT LOSS THERAPY 2019, VOLUME: 4 | DOI: 10.4172/2165-7904-C2-093