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Find More Information @ March 2019 Conference Series LLC Ltd
conferenceseries LLC Ltd
19th International Conference on
Obesity, Healthcare - Nutrition & Fitness
March 18 - 19, 2019 | New York, USA
JOURNAL OF OBESITY &WEIGHT LOSS THERAPY 2019, VOLUME: 4 | DOI: 10.4172/2165-7904-C2-093 SCIENTIFIC TRACKS | DAY 1
Genomics of the obese
patient before and after
bariatric surgery
Darlene Antoine
Lorraine University Faculty of
Medicine, France
Obesity is today a worldwide
clinical and public health
burden. It is associated with
an increased risk of type
2 diabetes, cardiovascular
disease, cancer, metabolic
syndrome, nonalcoholic
steatohepatitis, and mortality.
The identification of multiple
genetic defects responsible
for monogenic syndromic and
non-syndromic, oligogenic and
polygenic forms of obesity over
the last 20 years confirm an
inherited component. A partial
genetic overlap has been
demonstrated between BMI
variation in general populations
and extreme forms of obesity.
However, little is known on
the genetic determinants of
BMI variation among obese
people. For this study, clinical
data were extracted from
the CHRU Lorraine’s patient
database. Blood was collected
during the surgery for DNA
extraction. The genotyping was
performed using 240k SNPs
Illumina BeadChip. Quality
control was performed using
GenomeStudio 2.0, Plink
considering a callrate  99%,
and callFreq 95%. The results
show that 169(48%) of patients
are carriers of at least 1 of
these mutations predisposing
to obesity, and 182 are non-
carriers, which explains that
carriers for these mutations
present 1.3 unit of BMI more
than in the general population
before the surgery. The
variants do not have effect on
weight loss in response to the
modifications due to lifestyle
and the surgery after 2, 7,
and 12 months. In summary,
the results suggest that rare
and low frequency genetic
variants associated with BMI
in a general population have
six times more effect on BMI
in the morbidly obese cohort.
and different genetic variants
control the response to obesity
lifestyle modification and
surgery.
Biography
She currently pursuing a PhD
degree at Lorraine University
Faculty of Medicine, Nancy,
France. I’m a second year
PhD student. She currently
writing 2 papers based on my
PhD project: Genomics of the
obese patient before and after
bariatric surgery. In the past,
during my masters she worked
in Cardiovascular Diseases at
the University of Ottawa Heart
Institute, and for that project I
have 2 publications in reputed
journals.