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19th International Conference on
Obesity, Healthcare - Nutrition & Fitness
March 18 - 19, 2019 | New York, USA
SCIENTIFIC TRACKS | DAY 2 JOURNAL OF OBESITY &WEIGHT LOSS THERAPY 2019, VOLUME: 4 | DOI: 10.4172/2165-7904-C2-093
The effect of 20
hydroxyeicosatetraenoic
acid antagonism on
myocardial infarction of
metabolic syndrome rats
Corinna Lozano
New York Medical College, USA
20-hydroxyeicosatetrae-
noic acid (20-HETE) is an
eicosanoid metabolite of that
has a wide range of effects
on the vascular system such
as collateral cell growth, the
vascular rebuilding of the
heart. Metabolic syndrome and
20-HETE have been shown to
be correlated together. There
is a higher concentration of 20-
HETE in Metabolic Syndrome
patients. With a higher con-
centration of 20-HETE patients
with metabolic syndrome
have symptoms that are more
severe. The effect of elevated
20-HETE is negative and can
influence cell growth after a
myocardial infarction. Myocar-
dial Infarction (MI) is another
term for a heart attack. In pre-
vious studies, it shows an MI
size increases with an elevated
level of 20-HETE. During the
study, the metabolic syndrome
rats and a control group of rats
will be induced with an MI for
about 30minutes. After rats
from both groups are given
an MI and 20-HETE antago-
nist named 20-SOLA which
counteracts 20-HETE levels
will be given. 20-SOLA treat-
ment was given to the rats at
48hours, 1 week and 8 weeks.
The results indicated that the
AMPK antibody for both total
and phosphorylated showed a
significant decrease in 48hour
samples. 20-SOLA was found to
create equilibrium in 20-HETE
levels in all tissue samples
and significantly more in JCR
MI rats. 20-SOLA aided the
decrease in ischemia for both
rats, but again results indicate
a more reliable significance in
JCR MI rats. These findings are
relevant to the epidemic of car-
diovascular diseases plaguing
populations globally.
Biography
Corinna Lozano is a junior and
a second year in the Science
Research program run through
SUNY Albany. She is a member
of peer leadership in which
she is the secretary and the
town of Pawling’s interact club.
She is an active participant in
soccer and dance team. When
Corinna is out of school she
enjoys spending time with
her family and volunteering
in her community. She is very
dedicated to working hard in
school and in her sports. She
is very friendly and enjoys
meeting new people through
school programs. Pawling High
School is a great environment
in which has been bettered by
her bright and cheery spirit.
The teachers of Pawling High
School all enjoy having her as
she is super helpful when her
fellow peers have a problem.
She is currently working with
her mentor on her research
project that focuses on the
effects of 20-HETE.