nutrition-2016_posters-accepted-abstracts

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Volume 6, Issue 5 (Suppl) J Nutr Food Sci
ISSN:2155-9600 JNFS, an open access journal
Page 62
Notes:
Nutrition 2016
September 14-16, 2016
conferenceseries.com
September 14-16, 2016 San Antonio, USA
6th International Conference and Exhibition on
Nutrition
Yen-Ting Tung, J Nutr Food Sci 2016, 6:5 (Suppl)
Effect of melatonin on growth and abnormal deposition of extracellular matrix component in
uterine leiomyoma cells
Yen-Ting Tung
Taipei Medical University of Nutrition and Health Sciences, Taiwan
Women suffering from leiomyoma account for a quarter of the world's female population. Studies indicate that leiomyoma may
be expanded by estrogen imbalance, abnormal deposition of extracellular matrix and stem cell proliferation. Melatonin is an
endogenous hormone produced by the pineal gland in the brain, can regulate physiological clock and secrete estrogen. In this study,
we investigated the antitumor effect of melatonin on leiomyoma and smooth muscle cell (ELT3, UtSMC) in vitro. We examined the
effects of melatonin on leiomyoma stem-like cells number, cell proliferation, cell cycle regulation, apoptosis or autophagy related
protein expression and accumulation of extracellular matrix. Melatonin significantly inhibited the proliferation of leiomyoma cell in a
dose-dependent and time-dependent manner. Melatonin reduced on leiomyoma stem-like cells number and induced leiomyoma cell
early and lately apoptosis. Melatonin induced apoptosis and autophagy related protein expression. Melatonin inhibited accumulation
of extracellular matrix on leiomyoma cell. These findings suggest that melatonin may inhibit leiomyoma cell proliferation and have
the potential to improve the development of leiomyoma associated with functional food.
Biography
Yen-Ting Tung is currently a student in Taipei Medical University of Nutrition and Health Sciences. He studies the effect of phytochemicals on leiomyoma and
cancer disease.