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conferenceseries
.com
Volume 5, Issue 3 (Suppl)
J Infect Dis Ther, an open access journal
ISSN:2332-0877
Infectious Diseases 2017
August 21-23, 2017
3
rd
Annual Congress on
Infectious Diseases
August 21-23, 2017 San Francisco, USA
Prevalence of
UMOD
gene mutation among Saudi patients with kidney failure
Saleh Ahmed Alogla
1
, Hussain Gadelkarim Ahmed
1
, Rayan Mohsen Ismael
1
, Abdulkarim Ali Alqufayi
1
, Saleh Othman Alamer
1
, Hamoud Khalid Alshaya
1
, Ibrahim
Abdelmageed Ginawi
1
and
Awdah M Al-hazimi
2
1
University of Hail, KSA
2
King Abdul-Aziz University, KSA
Background:
Mutations in the uromodulin (
UMOD
) gene lead to a dominant hereditary renal disease, which may ultimately
result in kidney failure. Therefore, the aim of this study was to assess the burden of
UMOD
associated renal among Saudi
patients with renal failure (RF).
Methodology:
PCR amplification of 10 exons (forward and reverse) enclosed in the
UMOD
gene is done on the patient's
genomic DNA of 103 Saudi patients with RF.
Results:
Of the 103 patients,
UMOD
gene
mutation was identified in 10/103 (9.7%).
Conclusion:
UMOD
gene
mutation is relatively prevalent among Saudi patients with RF. Further evaluation of different
mutations in this gene is important for overall assessment of its role in RF among Saudi population.
Biography
Saleh Ahmed Alogla present is a student of Medical college in University of Hail, Saudi Arabia.
Aloglasaleh@gmail.comSaleh Ahmed Alogla et al., J Infect Dis Ther 2017, 5:3 (Suppl)
DOI: 10.4172/2332-0877-C1-027