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Volume 6
Journal of Infectious Diseases and Therapy
ISSN: 2332-0877
Infection Congress 2018
March 01-02, 2018
March 01-02, 2018 Berlin, Germany
5
th
International Congress on
INFECTIOUS DISEASES
Antibiotic resistance profile among gram-negative bacterial pathogens from a teaching hospital in
Ghana
Nicholas Agyepong
University of KwaZulu Natal, South Africa
I
nfections caused by antibiotic resistant gram-negative bacteria have become a major challenge to healthcare delivery in
Ghana. Production of beta-lactamase mediated-hydrolytic enzymes such as extended spectrum beta lactamases (ESBLs) or
combined with other mechanisms confers resistant to beta-lactam antibiotics (penicillins, cephalosporins and carbapenems)
as well as non-beta-lactams in gram-negative bacteria. The study aimed to assess the prevalence of antibiotic resistance among
gram-negative bacteria in the Komfo Anokye Teaching Hospital in the Ashanti region of Ghana. Bacterial cultures were
collected and identified using standard microbiological techniques and Vitek-2 automated systems. Of 200 isolates collected,
192 (96%) showed resistant to multiple antibiotics classes tested. The isolates
(Klebsiella pneumoniae, Acinetobacter baumannii,
Pseudomonas aeruginosa and Enterobacter spp, E. coli, Citrobacter koseri, Pantoea spp, Serratia marcescen, Providencia
rettgeri and Sphingomonas paucimobilis)
showed high resistance to ampicillin (95%), trimethoprim/sulfamethoxazole (84%),
cefuroxime/axetil (82%), cefuroxime (81%), cefotaxime (73.5%), amoxicillin/clavulanic acid (52.50), ciprofloxacin (41.0%)
and piperacillin- tazobactam (13.00%), but highly sensitive to ertapenem (98.48%), meropenem (96.98%), imipenem (96.5%),
amikacin (87%) and colistin (81.9%). The high resistance to beta-lactam/beta-lactamases inhibitor combination antibiotic
therapy and aminoglycosides and fluoroquinolones, poses serious healthcare threat in Ghana, due to their use as an empirical
antibiotic of choice for treatment of common infections. This study revealed a high prevalence of multidrug resistant pathogens
in Komfo Anokye Teaching Hospital, is rife and a wakeup call for constant review of antibiotic guideline protocol for treatment
is recommended. Finally the outcome of the study provides a baseline for further and extensive research into the underlying
molecular factors of the evolving resistance in Ghana
.
agyanicho33@yahoo.comJ Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C1-039