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Volume 7, Issue 5 (Suppl)
J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal
Biotechnology 2017
November 13-14, 2017
November 13-14, 2017 Osaka, Japan
19
th
World Congress on
Biotechnology
Cell function-based high-throughput screening of natural and synthetic compounds
Amandio Vieira
Simon Fraser University, Canada
M
odulators of cell functions such as transport pathways, signal transduction and redox balance may have biomedical
applications as pharmaco-therapeutics. We have developed biochemical and cellular high-throughput screening assays
to assess activities of natural products, standardized plant extracts, as well as synthetic compounds and biosimilars. Several of
these assays will be discussed in the context of (1) pro-oxidative and other pathological effects of misfolded and aggregated
polypeptides in amyloidogenic diseases, (2) infectious diseases involving endocytosis of the microbe and (3) epigenetic
regulation in metabolic disorders. Medicinal and dietary plant extracts, purified phytochemicals including flavonoids and
nutrients, as well as combinations of purified compounds, are currently undergoing screening in our laboratory and the latest
results will be presented.
Biography
Amandio Vieira has completed his BSc and PhD studies in Alberta, Canada and Postdoctoral studies in California, USA. He is currently Associate Professor and
the Director of the Nutrition and Metabolism Research Laboratory, Biomedical Physiology department, Simon Fraser University, Burnaby, Canada. He has over 90
publications, including research papers in major International journals, with over 1500 citations. He has served as Reviewer and Editorial Board member for journals
related to biomedical research, molecular and cellular biology, as well as educational and scientific books.
avvieira@sfu.caAmandio Vieira, J Biotechnol Biomater 2017, 7:5 (Suppl)
DOI: 10.4172/2155-952X-C1-082