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Volume 7, Issue 5 (Suppl)
J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal
Biotechnology 2017
November 13-14, 2017
November 13-14, 2017 Osaka, Japan
19
th
World Congress on
Biotechnology
Combination of bacterial cellulose wound dressing, silk sericin and polyhexamethylene biguanide for
wound healing
Supamas Napavichayanun and Pornanong Aramwit
Chulalongkorn University, Thailand
W
ound dressing is an important factor for wound treatment. The good properties of wound dressing will lead to
accelerate wound healing. Therefore, the objective of this study was to develop the bacterial cellulose wound dressing
containing silk sericin and polyhexamethylene biguanide (PHMB) for wound treatment. Coconut is one of the value products
of Thailand’s industrial harvests. Unfortunately, ripe coconut water is usually a waste product from coconut milk production
that is discarded into the environment and results in pollution. Bacterial cellulose is produced by
Acetobacter xylinum
which is
fermented in ripe coconut water. It has many advantages for wound healing: transparency, autolytic debridement, acceleration
of re-epithelialization and fewer daily wound dressing changes. Because of the many benefits of bacterial cellulose, it is used in
many applications including cosmetics and medical devices such as wound treatment dressing material. Silk sericin is a protein
from silk cocoons which can accelerate the proliferation of fibroblast cells and activate collagen synthesis for wound healing.
PHMB is a broad-spectrum antimicrobial agent with high efficacy and low toxicity. Accordingly, the combination of bacterial
cellulose wound dressing containing silk sericin and PHMB will have many benefits to the wound. The safety and efficacy of the
dressings,
in vitro
and
in vivo
was investigated. The results showed the dressing has good physical, mechanical and biological
properties. The wound size of wounds treated with the dressing showed a significantly less than control. No inflammation or
irritation was shown in rats. Moreover, in the clinical study, the dressing also showed many benefits for split-thickness skin
graft wound treatment without any toxicity.
Biography
Supamas Napavichayanun is a PhD student, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Thailand. She has obtained BSc from Faculty of
Phamaceutical sciences, Chulalongkorn University. Her research experience ranged from protein including silk proteins and biomaterials. She also did clinical
researches in the area of dermatology especially materials for wound healing application.
snsupamas@gmail.comSupamas Napavichayanun et al., J Biotechnol Biomater 2017, 7:5 (Suppl)
DOI: 10.4172/2155-952X-C1-082