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Volume 7, Issue 5 (Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal Biotechnology 2017
November 13-14, 2017
November 13-14, 2017 Osaka, Japan
19th World Congress on
Biotechnology
Anti-inflammatory activity of Scirpus tabernaemontani on LPS-stimulated RAW 264.7 macrophage cells
Min-Jin Kim and Sang Cheol Kim
Nakdonggang National Institute of Biological Resources, South Korea
The stem of Scirpus tabernaemontani, one of the aquatic plants, has been reported to have been used as a medicinal herb,
but lacks a scientific basis. Also, it is unknown whether Scirpus tabernaemontani extract (STE) modulate the inflammatory
response in RAW 264.7 macrophage cells. The present study was therefore designed to elucidate the pharmacological and
biological effects of STE on the production of pro-inflammatory cytokines and inflammatory mediators in macrophages. The
results indicate that STE is an effective inhibitor of LPS-induced NO and PGE2 production in RAW264.7 cells. And STE
could effectively inhibit the LPS-induced production of pro-inflammatory cytokines such as IL-6, TNF-α and IL-1β in a
concentration-dependent manner. These results suggest that STE attenuated the LPS-induced release of pro-inflammatory
mediators and cytokines probably via suppressing the activation of MAPK (JNK, ERK and p38) and NF-κB signaling. To assess
the suitability of STE for cosmetic applications, we also performed MTT assays on HaCaT keratinocytes. STE did not display
any cytotoxicity in these assays. In conclusion, this study not only provides more evidence that STE exerts anti-inflammatory
activity in macrophage cells, but also sheds light on the potential use of STE as an attractive candidate for treatment of various
inflammation-associate disease.
Biography
Min-Jin Kim has majored in Molecular Cell Biology and has been studying biologically active materials using primarily natural materials. Currently, she is a member
of the Nakdonggang National Institute of Biological Resources focusing on freshwater biological resources and is conducting research on the validity, composition
analysis and practical application of freshwater biological resources for exploration, conservation and development.
Min-Jin Kim et al., J Biotechnol Biomater 2017, 7:5 (Suppl)
DOI: 10.4172/2155-952X-C1-083