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conferenceseries
.com
Volume 8
Journal of Biotechnology & Biomaterials
ISSN: 2155-952X
Biotech Congress 2018 & Enzymology 2018
March 05-07, 2018
JOINT EVENT
20
th
Global Congress on
Biotechnology
3
rd
International Conference on
Enzymology and Molecular Biology
&
March 05-07, 2018 London, UK
Recent Publications
1. Passos D O, Li M, Yang R, Rebensburg S V, Ghirlando R (2017) Cryo-EM structures and atomic model of the HIV-1
strand transfer complex intasome. Science. 355(6320):89-92.
2. Kessl J J, Kutluay S B, Townsend D, Rebensburg S, Slaughter A et al. (2016) HIV-1 integrase binds the viral RNA
genome and is essential during virion morphogenesis. Cell. 166(5):1257-1268.
3. Sharma A, Slaughter A, Jena N, Feng L, Kessl J J (2014) A new class of multimerization selective inhibitors of HIV-1
integrase. PLoS Pathog. 10(5):e1004171.
4. Jurado K A, Wang H, Slaughter A, Feng L, Kessl J J et al. (2013) Allosteric integrase potency is determined through the
inhibition of HIV-1 particle maturation. Proc. Natl. Acad. Sci. USA. 110(21):8690-8695.
5. Hoyte A C, Jamin A V, Koneru P C, Kobe M J, Larue R C (2017) Resistance to pyridine-based inhibitor KF116 reveals
an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing. J Biol Chem. 292(48):19814-
19825.
Biography
Mamuka Kvaratskhelia began his independent research career at the Ohio State University in 2003 and has focused on better understanding of the structure and
function of HIV-1 integrase as a therapeutic target. He has recently (2017) moved to University of Colorado Denver as a Professor of Medicine (Infectious Diseases)
to further extend his studies on HIV-1 integrase. By employing innovative biochemical, biophysical, structural biology, molecular biology and virology approaches,
his research team has made many important contributions to the field, which include the discovery of second, non-catalytic role of integrase in HIV-1 biology and
elucidating the mode of action of ALLINIs.
mamuka.kvaratskhelia@ucdenver.edu