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Volume 8, Issue 6 (Suppl) J Bioequiv Availab
ISSN: 0975-0851 JBB, an open access journal
Page 32
Notes:
Biopharma 2016
September 14-16, 2016
conferenceseries.com
September 14-16, 2016 San Antonio, USA
2nd International Conference & Expo on
Biopharmaceutics and Biologic Drugs
Epigenetic change of genome by peptide bioregulators in extreme old age
Teimuraz Lezhava, Jokhadze T and Monaselidze J
Tbilisi State University, Georgia
Purpose: The objective of the present investigation is to study the modification of chromosome (total heterochromatin, constitutive
and facultative heterochromatin) under the influence of peptide bioregulators (Ala-Glu-Asp-Gly, Ala-Glu-Asp-Pro, Lus-Glu-Asp-
Ala and Lys-Glu) and heavy metal in cultured lymphocytes derived from old individuals.
Methods: The level of total heterochromatin - identified by the method of differential scanning microcalorimetry; the level of
facultative heterochromatin – by the method of sister chromatid exchanges (SCE), level of satellite stalk and C-heterochromatin
under the combined effect of bioregulators and Co Cl2 have been studied in lymphocyte cultures from individuals at the age of 80
and over.
Results:The results showed that: 1) epigenetics processes – progressive heterochromatinization of total, constitutive (pericentromeric,
telomeric and NOR heterochromatin) and facultative heterochromatin occurred with aging; 2) peptide bioregulators induce
deheterochromatinization of chromosomes in old age; 3) higher level of SCEs (deheterochromatinization) were registered in
precentromeric and telomeric heterochromatin upon combined effect of Co ions and peptide bioregulators.
Conclusions: The proposed genetic mechanism responsible for constitutive and facultative heterochromatin epigenetic change
(hetero- and deheterochromatinization pericentromeric and telomeric region) of old age may lead to the development of therapeutic
treat.
Biography
Lezhava T has discovered that the progressive heterochromatinization occurs in aging and his scientific works are generally dedicated to the problem Genetics
of Aging. He delivers lectures in Genetics, Human Genetics with the Fundamentals of Molecular Genetics, Medicine Genetics and Evolution of Genome. He is a
Member of Editorial Board of journals like: “Georgian Medical News”; “Gerontology and Geriatric Research” (NJ, USA); Jacobs Journal of Gerontology (Texas,
USA); Edition “Inter ging” and Journal of Deutscher Wissenschaftsherold (Germany); Journal of Biomedicina (Russia). He is a member of the International
Association and USA of Biomedical Gerontology, President of Georgian Gerontology Association, Head of Georgian Human Genetic Association and member of
several local and foreign Scientific Academies.
Teimuraz Lezhava et al., J Bioequiv Availab 2016, 8:6 (Suppl)