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Volume 8, Issue 6 (Suppl) J Bioequiv Availab
ISSN: 0975-0851 JBB, an open access journal
Page 27
Notes:
Biopharma 2016
September 14-16, 2016
conferenceseries.com
September 14-16, 2016 San Antonio, USA
2nd International Conference & Expo on
Biopharmaceutics and Biologic Drugs
Search of co-solvents of poorly water-soluble bioactive compounds in natural products on the basis of the
solubility measurements
Hiroyuki Matsuda, Kiyofumi Kurihara, Katsumi Tochigi and Kazuo Tomono
Nihon University, Japan
The object of this study is to search a suitable co-solvent of poorly water-soluble bioactive compounds in natural products on
the basis of the solubility measurements. In this study, curcumin (diferuloymethane), the Indian solid gold, the major active
component of turmetic, was selected as a model bioactive compound. Curcumin is used as a spice in curry and as a coloring agent
in yellow mustards, cosmetics, and pharmaceuticals. It has attracted great interest because of its antioxidant, anti-inflammatory, and
potential cancer chemopreventive activities. However, the major problem with curcumin is its extremely low solubility in aquous
solution and poor bioavailability. If addition of a suitable co-solvent makes an enhancement of solubilities of curcumin, it would be
useful for the development of drug or functional food which an efficient systemic absorption is available. In this work, several β-CD
derivatives, e.g., 2-hydroxypropyl- (2-HP-), sulfobutyl ether (SBE-), and methyl- (M-) β-CDs, were investigated as a co-solvent. The
solubilities of curcumin in water + CD mixed solvents, and a suitable co-solvent for an enhancement of the solubilities in curcumin
was examined. The solubilities of curcumin in water + CD mixed solvents at 298.15 K were determined using high-performance
liquid chromatography (HPLC). Enhancement in the solubility of curcumin could be achieved in all β-CD derivatives. Maximum
solubilization shows M-β-CD, and follows SBE-β-CD and 2-HP-β-CD. Stability constants kc were evaluated by Takeru Higuchi-
Konnors solubility method. The order of the determined stability constants were M-β-CD > SBE-β-CD > 2-HP-β-CD.
Biography
Hiroyuki Matsuda has completed his PhD from Nihon University. His research field is Chemical Engineering Thermodynamics. He is the Associate Professor of
Nihon University. He has published more than 30 papers in reputed journals.
Hiroyuki Matsuda et al., J Bioequiv Availab 2016, 8:6 (Suppl)