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Volume 8, Issue 6 (Suppl) J Bioequiv Availab
ISSN: 0975-0851 JBB, an open access journal
Page 29
Notes:
Biopharma 2016
September 14-16, 2016
conferenceseries.com
September 14-16, 2016 San Antonio, USA
2nd International Conference & Expo on
Biopharmaceutics and Biologic Drugs
Investigation of the biochemical mechanism of action of antioxidants in the prevention of cancer
Kissi Mudie
Ethiopian Public Health Institute, Ethiopia
Background: Cancer refers to a group of diseases that are associated with a disturbance in the control of cell growth and metabolism.
Indeed, the unbalanced control of cellular proliferation is a primary characteristic of cancer cells and, as such, any molecule capable
of inhibiting cancer cell proliferation may also be useful as a potential chemo-preventive agent. Throughout history, antioxidants have
been the most significant source of anticancer and chemopreventing agents. More than 1,000 different phytochemicals are already
proved to possess interesting chemopreventing activities. Antioxidants consist of a wide variety of biologically active phytochemicals
including phenolics, flavonoids, carotenoids, etc., that have been shown to suppress early and late stages of carcinogenesis.
Objective: To review recent biochemical and molecular mechanisms, in relation to natural and synthetic chemopreventing substances
(antioxidants) for cancer control and management.
Major Findings: Antioxidants exert anticancer effects via a variety of mechanisms, including removal of carcinogenic agents,
modulation of cancer cell signaling and cell cycle progression, promotion of apoptosis and modulation of enzymatic activities.
Conclusion: This review provides an updated and comprehensive overview on the anticancer effects of antioxidants in-vitro and
in-vivo animal models including recent intervention studies. Finally, possible mechanisms of action involving antioxidant and pro-
oxidant activity as well as interference with cellular functions are discussed.
Biography
Kissi Mudie has completed his MSc in Medical Biochemistry from Addis Ababa University, School of Medicine. He is the Director of National Clinical Chemistry
Laboratory, Ethiopian Public Health Institute. He has published more than 14 papers in reputed journals and has been serving as an Associate Researcher.
Kissi Mudie, J Bioequiv Availab 2016, 8:6 (Suppl)