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Volume 8, Issue 6 (Suppl) J Bioequiv Availab
ISSN: 0975-0851 JBB, an open access journal
Page 33
Notes:
Biopharma 2016
September 14-16, 2016
conferenceseries.com
September 14-16, 2016 San Antonio, USA
2nd International Conference & Expo on
Biopharmaceutics and Biologic Drugs
Design and evaluation of press coated pulsatile release tablets of Prednisolone
Upendra L Patel
Arihant School of Pharmacy and Bio-Research Institute, India
To formulate and evaluate a press coated pulsatile release tablets of prednisolone using an admixture of hydrophilic polymer,
i.e., low substituted hydroxy propyl cellulose (L-HPC) and hydrophobic polymer, i.e., ethyl cellulose (Ethocel 10 cps) in order
to achieve a pre-determined lag time for chronotherapy of rheumatoid arthritis. The press coated pulsatile tablets containing
prednisolone in the inner core were prepared by compression coating with L-HPC and Ethocel 10 cps as the outer layer in different
ratios. The effect of polymer ratio and weight gain of the outer layer on lag time of drug release was investigated using 32 full factorial
design. The parameters determined were tablet hardness, friability, drug content, lag time, dissolution. The release profile
of the press coated tablet exhibited a distinct lag time before burst release of prednisolone. Lag time was dependent on the ratio of
L-HPC/Ethocel 10 cps and weight gain in outer shell. The lag time was from 1 to 10 hr and could be modulated as it decreased as the
amount of L-HPC in the outer layer increased. A surface plots are also presented to graphically represent the effect of independent
variables on the lag time. The validity of generated mathematical model was tested by preparing checkpoint formulation. Formulation
PCPT7 with L-HPC/Ethocel 10 cps (10:90) and weight gain 300 mg showing predetermined lag time of 5 hr prior to burst release of
the drug from the press coated tablet was taken as the optimized formulation.
Biography
Upendra L Patel has completed his PhD from Sardar Patel University, Anand, Gujarat, India in 2010. He is the Head of Department & Associate Professor in
Department of Pharmaceutics & Pharmaceutical Technology in Arihant School of Pharmacy & BRI, Gujarat, India. His area of research is formulation and evaluation
of controlled drug delivery formulations. He has guided more than 25 MPharm students. He has published more than 40 papers in reputed journals and one book
“Dispensing Pharmacy & Drug Store Management”. He is life time member of Gujarat Pharmacy Teacher Associations.
Upendra L Patel, J Bioequiv Availab 2016, 8:6 (Suppl)