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Volume 8, Issue 6 (Suppl) J Bioequiv Availab
ISSN: 0975-0851 JBB, an open access journal
Page 28
Notes:
Biopharma 2016
September 14-16, 2016
conferenceseries.com
September 14-16, 2016 San Antonio, USA
2nd International Conference & Expo on
Biopharmaceutics and Biologic Drugs
Acacia catechu Willd extract: A nutraceutical approach to gastrointestinal pathologies
Matteo Micucci, Alberto Chiarini, Carla Marzetti, Luca Camarda, Roberto Gotti and Roberta Budriesi
University of Bologna, Italy
Gastro-intestinal infections constitute important emerging and re-emerging infective worldwide diseases.They are mostly endemic
and show a heterogeneous aetiology. Most water-borne diseases caused by microorganisms induce diarrhoea and determine
about 5 million deaths per year. The research on anti-diarrheal tools should be focused on the evaluation of substances and chemically
charachterized phytocomplexes able to affect intestinal motility and to exert a prebiotic action. Several plants, such as Castanea sativa
Mill., Sanseviera liberica Gerome & Labroy, have been shown to inhibit gut peristalsis, through several mechanisms. Furthermore,
disparate classes of natural compounds including hydrolysable tannins and flavonoids, restore intestinal functionality, affecting
different molecular networks influencing each other’s. Acacia catechu Willd extract (ACE) has been used in Indian Traditional
Medicine to manage several diseases including diarrhoea and other gastrointestinal ailments. This extract was shown to contain high
amounts of flavonoids, in particular flavan-3-ols. Furthermore, in vitro biological assays were exerted, using tissues from guinea
pigs, to assess ACE effects towards induced and spontaneous intestinal smooth muscle contractility. The results demonstrated that
ACE reducecs spontaneous and induced colon and ileal smooth muscle contractility via inhibiting muscarinic and histaminergic
receptors. Also ACE effects against several pathogenic and non pathogenic bacteria were tested, showing a selective antibacterial
activity towards pathogenic strains including, Staphylococcus aureus, Gram-negative Escherichia coli, Salmonella spp., Campilobacter,
without inhibiting. These findings suggest that Acacia may represent a nutraceutical option to manage diarrheal infectious and non
infectious disesases.
Biography
Matteo Micucci has completed his PhD from Bologna University and continues his research focused on Medicinal Chemisrty and Nutraceuticals at Department
of Pharmacy and Biotechnology, University of Bologna. He had spent three months period, as visiting PhD Student, in the Research Laboratory of Medicinal
Chemistry of De Montfort University (DMU), Leicester, UK. He has published 19 papers in reputed journals and is Science Adviser in the field of Nutraceuticals,
Alternative and Complementary Medicines, at Segreteria Particolare of a Senator of the Italian Republic, from October 12th, 2015 till date.
Matteo Micucci et al., J Bioequiv Availab 2016, 8:6 (Suppl)