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Bio Summit & Molecular Biology 2016
October 10-12, 2016
Volume 6, Issue 6(Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal
conferenceseries .com
October 10-12, 2016 Dubai, UAE
2nd World Congress on
Bio Summit & Molecular Biology Expo
Kashaf Junaid et al., J Biotechnol Biomater 2016, 6:6(Suppl)
Role of vitamin D deficiency in susceptibility to tuberculosis and treatment response
Kashaf Junaid1, 2, Abdul Rehman2 and Tahir Saeed3
1University of the Punjab, Pakistan
2The University of Lahore, Pakistan
3Gulab Devi Chest Hospital, Pakistan
Vitamin D, a fat soluble vitamin, is well known for calcium homeostasis. Deficiency of vitamin D is not only linked with
rickets or osteomalacia but with many other infectious and metabolic disorders. Emerging evidences suggest the relation
of vitamin D deficiency in tuberculosis. The objectives of this study were to investigate the association of vitamin D deficiency
with tuberculosis and to see its impact on anti-tuberculous response. We recruited 260 TB patients from Gulab Devi Chest
Hospital, Lahore who had yet not started anti TB treatment for this admission. Any patient with co morbidity or age above 60
years was excluded. Serum 25(OH) D was measured in TB cases, contacts of TB patients and controls from general population.
Baseline vitamin D status was significantly associated with TB (P<0.01). Mean vitamin D level in TB patients was 23 nmol per
L which is much lower than TB contacts and controls from general population. Sputum smear sample for the presence of acid
fast bacilli was examined after every two weeks for all included cases, till sputum converted negative for AFB. Survival analysis
indicates that patients with deficiency of vitamin D required more time to sputum smear conversion (median days 22.5, IQR
22.5-37.5). And this association of vitamin D with response to anti-tuberculous treatment was genotype independent. Allelic
discrimination assay for VDR, CYP2R1 and VDB indicate none of these SNPs are associated with vitamin D deficiency and
not with incidence of tuberculosis. High prevalence of vitamin D deficiency in pulmonary TB patients indicates that vitamin
D is a risk factor for the development of active tuberculosis. Furthermore, its impact in response to anti-tuberculous treatment
also explains its significant role in the management of tuberculosis. As early sputum smear conversion can break the chain of
infection and further spread of tuberculosis. Therefore, maintaining vitamin D status in TB patients might be helpful to control
tuberculosis.
Biography
Kashaf Junaid has completed her PhD from the Department of Microbiology and Molecular Genetics, University of The Punjab, Pakistan. She also did research
work in Bart’s Institute of Primary Health Care, Queens Mary University of London. She is working as an Assistant Professor in The University of Lahore, Pakistan.