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Bio Summit & Molecular Biology 2016
October 10-12, 2016
Volume 6, Issue 6(Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal
conferenceseries .com
October 10-12, 2016 Dubai, UAE
2nd World Congress on
Bio Summit & Molecular Biology Expo
Farah Ibrahim Al-Marzooq et al., J Biotechnol Biomater 2016, 6:6(Suppl)
The oral microbiome and salivary biomarkers in health and disease
Farah Ibrahim Al-Marzooq1 and Natheer Al-Rawi 2
1Research Institute of Medical & Health Sciences, University of Sharjah , UAE
2College of Dental Medicine, University of Sharjah , UAE
The oral microbiome plays a relevant role in human health and it is a key element in a variety of oral and systemic diseases.
There is a relation between oral and systemic diseases, but the question remains whether the oral diseases are the cause
or the consequence of pathological process in other body sites. We aim to compare the bacterial community and the level of
selected biomarkers in the saliva of adults in health and disease conditions. 90 saliva samples were collected from three equal
groups (obese with diabetes, obese without diabetes and healthy control). Resistin (a biomarker of insulin resistance) was
measured in saliva using ELISA technique. Real-time PCR was used to quantify selected bacterial species associated with oral
infections. Salivary resistin was significantly higher in the obese patients (diabetics and non-diabetics) compared to the healthy
control. Fusobacterium (associated with gingivitis), Porphyromonas gingivalis and Tannerella forsythia (associated with
periodontitis) were detected in significantly higher quantities in the obese patients (diabetics and non-diabetics) compared
to the healthy control. No correlation was found between the levels of salivary resistin and different oral bacteria. This study
highlighted the importance of saliva as a non-invasive sample for the detection of biomarkers and microbes associated with
oral and systemic diseases. This may pave the way for more effective diagnostic and therapeutic methods which can contribute
to the development of personalized medicine and personalized dental medicine.
Biography
Farah Ibrahim Al-Marzooq is a medical doctor specialized in microbiology. She has completed her PhD degree (with thesis distinction) from the Department of
Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia in 2015. During her PhD study, she was able to identify 3 novel gene
varients (related to antibiotic resistance) reported for the first time at the global level. She is currently working as a postdoctoral research associate in the Research
Institute of Medical & Health Sciences , University of Sharjah , UAE. Her research work was published in several reputable international journals.