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Bio Summit & Molecular Biology 2016
October 10-12, 2016
Volume 6, Issue 6(Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal
conferenceseries .com
October 10-12, 2016 Dubai, UAE
2nd World Congress on
Bio Summit & Molecular Biology Expo
Mohammad Farahmandnia et al., J Biotechnol Biomater 2016, 6:6(Suppl)
ROS might just be a sideshow: Exploring simultaneous observation of mTORC1 activity and
increase in ROS
Mohammad Farahmandnia, Mohammadreza Dorvash and Mohammadhossein Khorraminejad-Shirazi
Shiraz University, Iran
There is huge debate regarding whether reactive oxygen species (ROS) are the cause for aging. Meta-analyses indicate
antioxidants have little effect, if any, on lifespan. This mandates the need for rethinking causality of ROS in senescence.
In this article, high quality studies (n=20) were sorted into three categories: Basic, clinical/meta-analytic and ROS-mTOR
relationship. Evidences were compared to discover inconsistencies and bigger-picture revelations. Studies showed simultaneity
of mTORC1 activity and increased ROS. Basic studies suggested that ROS causes cell damage and genomic instability leading to
aging. Nevertheless, meta-analyses clarify antioxidants have literally zero outcome affecting lifespan. This questions the causal
role of ROS in senescence. Considering that hyperactive mTORC1 intensifies aging while decreasing ROS has little benefit,
ROS could be thought of as mere chemical byproducts with no causal role and can be eliminated from the picture. This new
perspective also indicates that it is the time to look for other roles for ROS rather than regarding it as the cause of senescence.
Biography
Mohammad Farahmandnia is a undergraduate Medical Doctor student at Shiraz University of Medical Science. He is a holder of Silver Medals in Biology and Basic
Medical Science Olympiads. He has also co-authored 6 papers in reputed journals on stem cell research. He is currently a Member of Cell and Molecular Medicine
Student Research Group\ with particular focus on systems biology of aging.