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conferenceseries
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Volume 9, Issue 9 (Suppl)
J Cancer Sci Ther, an open access journal
ISSN: 1948-5956
World Cancer 2017
October 19-21, 2017
25
th
WORLD CANCER CONFERENCE
October 19-21, 2017 | Rome, Italy
Senescent tumor cells lead the collective invasion in thyroid cancer
Young Hwa Kim
Ajou University School of Medicine, South Korea
C
ellular senescence has been perceived as a barrier against carcinogenesis. However, the senescence-associated secretory
phenotype (SASP) of senescent cells can promote tumorigenesis. Here, we show senescent tumour cells are frequently
present in the front region of collective invasion of papillary thyroid carcinoma (PTC), as well as lymphatic channels and
metastatic foci of lymph nodes. In in vitro invasion analysis, senescent tumour cells exhibit high invasion ability as compared
with non-senescent tumour cells through SASP expression. Collective invasion in PTC is led by senescent tumour cells
characterized by generation of a C-X-C-motif ligand (CXCL)12 chemokine gradient in the front region. Furthermore,
senescent cells increase the survival of cancer cells via CXCL12/CXCR4 signalling. An orthotopic xenograft in vivo model also
shows higher lymphatic vessels involvement in the group co-transplanted with senescent cells and cancer cells. These findings
suggest that senescent cells are actively involved in the collective invasion and metastasis of PTC.
Biography
Young Hwa Kim has completed all the requirements for the Doctoral Degree in Biomedical Science and expect to obtain the Ph.D. Degree Certificate at the end of
February 2016, officially. She has published 8 papers, out of which she is the first author of 4 papers.
skyblue32@nate.comYoung Hwa Kim, J Cancer Sci Ther 2017, 9:9(Suppl)
DOI: 10.4172/1948-5956-C1-112