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conferenceseries
.com
Volume 9, Issue 9 (Suppl)
J Cancer Sci Ther, an open access journal
ISSN: 1948-5956
World Cancer 2017
October 19-21, 2017
25
th
WORLD CANCER CONFERENCE
October 19-21, 2017 | Rome, Italy
Anti-cancer effects of less polar Curcumin analogues on gastric adenocarcinoma and esophageal
squamous cell carcinoma cells
Fatemeh Alibeiki
Ardabil University of Medical Sciences, Iran
C
urcumin and its chalcone derivatives inhibit the growth of human cancer cells. It is reported that replacement of two OH
groups in curcumin with less polar groups like methoxy increases its antiproliferative activity. In this study, we explored
benzylidene cyclohexanone derivatives with non-polar groups, to see if they possess increased anti-cancer activity. Novel 2,6-
bis benzylidene cyclohexanone analogues of curcumin were synthesized, and their inhibitory effects on gastric adenocarcinoma
(AGS) and esophageal squamous cell carcinoma (KYSE30) cancer cells were studied using an MTT assay. Cell apoptosis was
detected by EB/AO staining, and cell cycle was analyzed by flow cytometry. Real-time PCR was performed for gene expression
analysis. All synthesized analogues were cytotoxic toward gastric and esophageal cancer cells and showed lower IC50 values
than curcumin. Treatment with 2,6-Bis-(3-methoxy-4-propoxy-benzylidene)-cyclohexanone (BM2) was 17 times more toxic
than curcumin after 48 h incubation. All novel compounds were more effective than curcumin in apoptosis induction and cell
cycle arrest at G1 phase. These results suggest that less polar analogues of curcumin have potent cytotoxicity
in vitro
. However,
they need to be investigated further, especially with animal tumor models, to confirm their chemotherapeutic activity
in vivo
.
Biography
Fatemeh Alibeiki has been studying at Ardabil University of Medical Sciences, Iran. Currently, she is in her final year of education as a medical student. So far, she
has published two papers in high-profile journals. Participating in numerous conferences and workshops is one of her interests and has done so, on a regular basis
throughout the years as a student which brought her experience, extensive knowledge and so many scientific certificates. She has also associated with different
groups in her university that resulted in holding several conferences and meetings.
fatemeh1991.ma@gmail.comFatemeh Alibeiki, J Cancer Sci Ther 2017, 9:9(Suppl)
DOI: 10.4172/1948-5956-C1-112