38 / 39
conferenceseries
.com
Page 77
Notes:
Volume 7, Issue 6 (Suppl)
J Biotechnol Biomater, an open access journal
ISSN: 2155-952X
World Biotechnology 2017
December 04-05, 2017
2
nd
World Biotechnology Congress
December 04-05, 2017 | Sao Paulo, Brazil
Chemical characterization and optimization of 4MHA pentapetide lactone from Streptomyces parvulus
C5-5Y
Arockiam Jeyasundar Parimala Gnana Soundari
1, 2
, Vellingiri Manon Mani
1, 2
, K P Salin
1
and
Venkatesan Brindha Priyadarisini
1
1
Bharathiar University, India
2
Hindusthan College of Arts and Science, India
Introduction:
The needs for increase in novel drugs urged to discover and develop new antibiotics with biopotentiality. The natural
products have been developed from medicinal plants and the recent research has mainly focused on the microbial sources for novel
antibiotics with bioactivities and this is economical in state. In this investigation we have developed a new bioactive compound with
maximum antioxidant and antimicrobial activities.
Methodology:
To increase the metabolite production as well as organism’s growth, we aimed to optimize the mediumwith economical
parameters and sources rapidly. This bioactive compound was elucidated from
Streptomyces parvulus
.
Results:
The maximum growth and pigment production was evaluated with the standard formula, and the production was higher
in optimal pH, temperature, carbon and nitrogen sources. The carbon sources are found to increase the growth of the organism
especially in starch. The mass production was obtained in the optimized medium and the extracted pigments were subjected to HPLC
analysis where the peak 4 was eluted and found to contain bioactivity through antimicrobial assessment. The compound AP4 was
structurally elucidated with raw data, finally the AP4 was 4MHA (4-Methyl 3-Hydroxy anthranilic acid) pentapeptide lactone and it
represents the half actinomycin structure with antioxidant properties.
Conclusion:
Further studies will be focused on two-dimensional NMR spectroscopy to confirm the structure and application of
pigment as pharma product in
in vivo
studies.
Biography
Arockiam Jeyasundar Parimala Gnana Soundari has explored her research in Microbial Biotechnology especially in microbial metabolites for human welfare and disease
prevention. Her experience has built many years in research and teaching which emphasizes student’s development in research areas. Her research is mainly focused to
create an economical antibiotics and pharmaceutical products from microbial origin and use it against dreadful diseases. Her foundation implies on separating a purified
bioactive metabolite and applies for various medicinal fields. This makes the society to get the antibiotics in low cost. This research is a promising strategy and successful
one which could be taking to higher degree levels for prevention of many diseases by microbial metabolites.
apgs_1987@yahoo.co.inArockiam Jeyasundar Parimala Gnana Soundari et al., J Biotechnol Biomater 2017, 7:6 (Suppl)
DOI: 10.4172/2155-952X-C1-085