56 / 61
Volume10, Issue 12 (Suppl)
J Proteomics Bioinform, an open access journal
ISSN: 0974-276X
Page 113
conferenceseries
.com
World Biomarkers & Pharma Biotech 2017
December 07-09, 2017
December 07-09, 2017 | Madrid, Spain
&
20
th
International Conference on
PHARMACEUTICAL BIOTECHNOLOGY
9
th
WORLD BIOMARKERS CONGRESS
JOINT EVENT ON
J Proteomics Bioinform 2017, 10:12(Suppl)
DOI: 10.4172/0974-276X-C1-110
Epigenomic hard drive (EHD) imprinting:Ahidden code within cancer cell to survive beyond the biological
death of a tumor patient
Nilesh Kumar Sharma
and
Pritish Nilendu
Dr. D Y Patil Vidyapeeth, India
S
everal genetic and epigenetic theories have been proposed to explain the intricacies of life and death. However, several questions
are still remaining unsettled with reference to the death event particularly of the living tissue in case of cancer patients such as
destination of cancer cells after the biological death of patients. Cancer can display the intent to communicate with the external
environment after the biological death of patient. Do they carry some special information in the form of coding that helps them
to survive? To explain such queries in cancer field, we hypothesize epigenomic hard drive (EHD) as a recording and storage of
global epigenetic events in cancerous and non-cancerous tissue of cancer patients. This mini-review presents the novel concept of
EHD reinforced with the existing knowledge of and genetic and epigenetic events in cancer. In conclusion, revealing such questions
will help to understand the tumor community as well as its role in pre and post death events. We propose that cancer cells being
a part of human cellular community may carry some encrypted coded message in the form of EHD and could be used beyond
the death decoding purpose about the individual life time any events, acts and activities. In future perspectives, state of the art
tools and techniques to decipher epigenetic landscape may provide answers to above proposed concept and could pave the way of
better understating of cancer, cellular death and human body death. The authors suggest that epigenetic tools based method such as
assessment of DNA methylation, histone code signature, small signaling messengers as miRNA could be performed on cancerous
and non-cancerous tissue during and after biological death of cancer patients. In this paper, we summarize the EHD understanding
may impart huge potential and interest for basic and clinical scientists to unravel mechanisms of carcinogenesis, therapeutic markers
and differential drug responses.
nilesh.sharma@dpu.edu.in