Volume10, Issue 12 (Suppl)
J Proteomics Bioinform, an open access journal
ISSN: 0974-276X
Page 110
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World Biomarkers & Pharma Biotech 2017
December 07-09, 2017
December 07-09, 2017 | Madrid, Spain
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PHARMACEUTICAL BIOTECHNOLOGY
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J Proteomics Bioinform 2017, 10:12(Suppl)
DOI: 10.4172/0974-276X-C1-110
Discovery and validation of biomarkers for allergy for use in dietary intervention studies
Karen Knipping
Nutricia Research, Netherlands
N
on-communicable diseases (NCDs) are becoming a real global problem and it is seen that allergies early in life are one of the
first signals of development of immune related disorders later in life. Therefore there is a substantial need to identify and validate
early, more specific, better and predictive and/or diagnostic biomarkers for allergy early in life. We have assessed the validity and the
predictive value for disease severity and/or response to treatment of the known biomarkers in clinical samples and found differences
in allergy-related biomarkers in atopic dermatitis, food allergy, asthma/rhinitis and eosinophilic esophagitis. To this date, no single or
specific biomarker for allergy has been identified. Since allergy is not one disease, but a collection of a number of allergic conditions,
it is therefore not very plausible that one marker would fit all, and probably a more holistic approach using a combination of clinical
history, clinical read-outs and diagnostic markers will be needed. The search for new and reliable biomarker will continue and the
evolution in biomarker discovery has resulted in an 'omics' approach, in which hundreds of biomarkers in the field of genomics,
transcriptomics, proteomics, and metabolomics can be simultaneously studied. A first attempt to identify new biomarkers for allergy
in matched serum and saliva samples of infants with atopic dermatitis versus healthy infants resulted in several potentially interesting
new markers which now have to be validated in upcoming studies.
Karen.Knipping@danone.com