traditional-medicine-2016_scientifictracks-workshop

Volume 5, Issue 2 (Suppl)

J Tradi Med Clin Natur

ISSN: JTMCN, an open access journal

Page 31

Notes:

Traditional Medicine 2016

September 14-16, 2016

conferenceseries

.com

September 14-16, 2016 Amsterdam, Netherlands

International Conference and Exhibition on

Traditional & Alternative Medicine

Protective effects of Urtica dioica seed extract in aflatoxicosis: Histopathological and biochemical findings

A Uyar, Z Yener

and

A Dogan

Yuzuncu Yil University, Turkey

he ameliorative potential and antioxidant capacity of an extract of

Urtica dioica

seeds (UDS) was investigated using

histopathological changes in liver and kidney of broiler, measuring serum marker enzymes, antioxidant defense systems and

lipid peroxidation (malondialdehyde (MDA) content in various tissues of broilers exposed to aflatoxin (AF). A total of 32 broilers

were divided randomly into 4 groups: control, UDS extract-treated, AF-treated and AF+UDS extract-treated. Broilers in control and

UDS extract-treated groups were fed on a diet without AF. The AF-treated group and AF+UDS extract-treated groups were treated

with an estimated 1 mg total AF/kg feed. The AF+UDS extract groups received in addition 30 ml UDS extract/kg diet for 21d. The

AF-treated group had significantly decreased body weight gain when compared to the other groups. Biochemical analysis showed a

small increase in the concentrations of serum aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transpeptidase

and lactate dehydrogenase in the AF-treated group compared to that of the control group, whereas concentrations of these enzymes

were decreased in the AF+UDS group compared to that of the AF-treated group. Administration of supplementary UDS extract

helped restore the AF-induced increase in MDA and reduced the antioxidant system towards normality, particularly in the liver,

brain, kidney and heart. Hepatorenal protection by UDS extracts was further supported by the almost normal histology in AF +UDS

extract-treated group as compared to the degenerative changes in the AF-treated broilers. It was concluded that UDS extract has a

protective hepatorenal effect in broilers affected by aflatoxicosis, probably acting by promoting the antioxidative defense systems.

A Uyar et al., J Tradi Med Clin Natur 2016, 5:2 (Suppl)