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conferenceseries
.com
Volume 4
Toxicology: Open Access
ISSN: 2476-2067
Toxicology Congress 2018
March 12-14, 2018
March 12-14, 2018 Singapore
14
th
World Congress on
Toxicology and Pharmacology
Amelioration of altered blood lipid level by imipramine in depressed rat
D S Mohale and A V Chandewar
P Wadhwani College of Pharmacy, India
Purpose:
The study was conducted to investigate the effect of imipramine on blood lipid parameters in depressed rat.
Methods:
Rats were subjected for 21 days social isolation; the rats displayed an increase in depression on force swim test
and tail suspension test relative to control. Various blood lipid parameters i.e. cholesterol, triglyceride, LDL and HDL were
determined.
Results:
There was significant increase in the level of cholesterol, triglyceride, LDL and decrease in the levels of HDL after
social isolation.
Conclusion:
The result of the present investigation showed that with the increase in the levels of depression, there is increase
in the blood lipid profile.
deepak.mohale@gmail.comToxicol Open Access 2018, Volume 4
DOI: 10.4172/2476-2067-C1-006