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conferenceseries
.com
Volume 4
Toxicology: Open Access
ISSN: 2476-2067
Toxicology Congress 2018
March 12-14, 2018
March 12-14, 2018 Singapore
14
th
World Congress on
Toxicology and Pharmacology
Risk assessment of N-nitrosodiethylamine (NDEA) and N-nitrosodiethanolamine (NDELA) in cosmetics
Byung-Mu Lee, Duck Soo Lim, Min Kook Kim and Yong Chan Kwon
Sungkyunkwan University, South Korea
N
-nitrosamine (N-nitrosodiethanolamine (NDELA), N-nitrosodiethylamine (NDEA)) and amine (triethanolamine
(TEA), diethanolamine (DEA)) levels in cosmetics were determined using validated liquid chromatography-tandemmass
spectrometry (LC-MS/MS) procedures. The impact of N-nitrosamine formation on the levels of TEA, DEA, nitrite and other
nitrosating agents was also studied. N-nitrosamine concentrations correlated with the number of nitrosating agents and nitrite
concentrations. Risk assessments, including the margin of exposure (MOE) and lifetime cancer risk (LCR) for N-nitrosamines
and the margin of safety (MOS) for amines, were calculated using product type, use pattern and concentrations. Exposure
to maximum amounts of NDELA and NDEA resulted in MOE>10,000 (based on the benchmark dose lower confidence
limit 10%) and LCR<1×10
-5
, respectively. Additionally, TEA and DEA in the cosmetic samples resulted in MOS values>100.
Therefore, no safety concerns were associated with cosmetic products containing NDELA, NDEA, TEA and DEA in this study.
However, since amines and nitrosating agents produce carcinogenic nitrosamines, their use in cosmetics should be minimized
to levels as low as technically feasible.
bmlee@skku.eduToxicol Open Access 2018, Volume 4
DOI: 10.4172/2476-2067-C1-006