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Volume 3, Issue 1 (Suppl) Toxicol Open Access
ISSN: 2476-2067 TYOA, an open access journal Toxicology Congress 2017
April 13-15, 2017
April 13-15, 2017 Dubai, UAE
8th World Congress on
Toxicology and Pharmacology
Acetaminophen induced hepatotoxicity: Preventive effect of gold nanoparticles
Mohd Salim Reshi and Sangeeta Shukla
Jiwaji University, India
Statement of the problem: Gold nanoparticles (AuNPs) exhibit amazing physical, chemical and biological properties and
have been widely used in medical applications like bio-imaging, drug delivery and photonics. The present study was aimed to
evaluate the therapeutic effect of AuNPs to protect the hepatotoxicity induced by Acetaminophen (APAP).
Methodology & Theoretical Orientation: Female Albino rats of Wistar strain were administered with APAP at a dose of 20
mg/kg p.o (5 days/week for 4 weeks). Animals were treated with AuNPs at a dose of 100 µg/kg p.o. and silymarin at a dose of
50 mg/kg p.o. for 2 days/week for 4 weeks.
Findings: APAP induced significant rise in hepatospecific markers which indicated the hepatocellular damage. APAP
administration exhibited substantial oxidative stress, regulation of proinflamatory cytokines and cellular DNA damage.
Biochemical analysis of antioxidant enzymes revealed significantly declined activities due to increased oxidative stress in APAP
exposed rats. Treatment with AuNPs significantly ameliorated the APAP induced
liver injury, oxidative stress and DNA damage, which can adversely affect the normal
cellular functioning in rats. Our biochemical investigations were also supported by
histological studies. The efficacy of AuNPs were comparable to the standard drug
silymarin, data indicated a positive effect.
Conclusion & Significance: It is concluded that AuNPs showed remarkable
amelioration against APAP induced toxicity. Thus it is concluded that AuNPs can
be used for the development of hepatoprotective drug after further preclinical and
clinical studies, which may raise a hope for the patients with hepatic disorders.
Biography
Mohd Salim Reshi completed his PhD from School of Studies in Zoology, Jiwaji University, Gwalior. He was awarded with JRF and SRF from UGC, New Delhi, India.
He has been awarded MP Young Scientist award and many other awards in several conferences and symposia. He is working on nanoparticles in hepatoprotection
and cancer prevention. His areas of research interest are Pharmacology, Toxicology, Hepatoprotection, Nanomedicine and Cancer Prevention.
Mohd Salim Reshi et al., Toxicol Open Access 2017, 3:1 (Suppl)
Figure (1): Showing the protective
effect of gold nanoparticles against
APAP toxicity