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Volume 3, Issue 1 (Suppl) Toxicol Open Access
ISSN: 2476-2067 TYOA, an open access journal Toxicology Congress 2017
April 13-15, 2017
April 13-15, 2017 Dubai, UAE
8th World Congress on
Toxicology and Pharmacology
Mass spectrometric imaging of rhizomes of Curculigo orchioides and their bioactivities
Deepa Yadav and Sangeeta Shukla
Jiwaji University, India
Statement of the Problem: Medicinal plants provide a wide range of secondary metabolites and play important role in the
treatment of serious disorders. Plants facilitate healing that is potent, profound and life affirming. The present study was aimed
to determine the secondary metabolites, antibacterial activity and anti-proliferative activity of Curculigo orchioides.
Methodology & Theoretical Orientation: The secondary metabolites of Curculigo orchioides were identified by gas
chromatography-mass spectrometry (GC-MS). Antibacterial activity was determined against bacterial strains Escherichia
coli, Pseudomonas aeruginosa, Streptococcus pyogenes and Staphylococcus aureus and
antiproliferative activity was evaluated against hepatocellular carcinoma (HepG2
cell line).
Findings: GC-MS analysis of alcoholic extract revealed the presence of
pharmacologically active compounds like d-Lyxo-d-manno-nononic-1,4-lactone;
3',8,8'-Trimethoxy-3-piperidyl-2,2'-binaphthalene-1,1',4,4'-tetrone; 7-Methyl-Z-
tetradecen-1-ol acetate; Paromomycin; Geranyl isovalerate; tert-Hexadecanethiol;
1,2-Propanediol, 3-(tetradecyloxy); n-Hexadecanoic acid; 9-Octadecenoic acid,
(2-phenyl-1,3-dioxolan-4-yl)methyl ester, trans and 2H-Cyclohepta[b] furan-2-one
and 6-[1-(acetyloxy)-3-oxobutyl] -3,3a,4,7,8,8a-hexahydro-7-methyl-3-methylene.
Alcoholic extract of Curculigo orchioides showed significant activity against bacterial
pathogens and HepG2 cell lines.
Conclusion & Significance: The data obtained from GC-MS can be used to study the therapeutic efficacy of secondary
metabolites, while alcoholic extract showed significant antibacterial and anti-proliferative activity.
Biography
Deepa Yadav is pursuing her PhD from School of Studies in Zoology, Jiwaji University, Gwalior, Madhya Pradesh. She was awarded with JRF of MPCST, Bhopal,
Madhya Pradesh. She has been awarded for best paper presentation by UGC-CRO Bhopal. She has published a book entitled Studies on T Cell Signalling
Mechanisms. Her areas of research interest include Molecular Immunology, Pharmacology, Toxicology and Cancer Prevention.
Deepa Yadav et al., Toxicol Open Access 2017, 3:1 (Suppl)
Figure (1): Showing identified
phytoconstituents and their
bioactivities.