toxicology-congress-2017-scientifictracks-abstracts

24 / 33

Page 61
conferenceseries.com
Volume 3, Issue 1 (Suppl) Toxicol Open Access
ISSN: 2476-2067 TYOA, an open access journal Toxicology Congress 2017
April 13-15, 2017
April 13-15, 2017 Dubai, UAE
8th World Congress on
Toxicology and Pharmacology
Characterization, cytotoxicity and genotoxicity of landfill leachates: A comparative assessment between
landfills throughout Lebanon
Christian Khalil, Rony Khnayzer and Cynthia El Hajjeh
Lebanese American University, Lebanon
Statement of the Problem: Lebanon has been witnessing a waste crisis in the last few years due to the closure of a main landfill
in Naameh as it exceeded storage capacity. The municipal waste crisis was years in the making because of the absence of a clear
national municipal waste minimization, recycling and disposal strategies with the preferred option being landfills throughout
the country. The disposition of municipal, medical, industrial and all wastes into landfills helped in short term waste disposal
but created a new challenge in the form of leachates. The purpose of this study was to assess the toxicological and health impacts
of leachates exposure by investigating a number of regulated and unregulated landfills scattered throughout the country.
Methodology &Theoretical Orientation: The study consisted of sampling leachates from numerous sites scattered throughout
the country. Some of the leachates at some sites were subjected to biological treatment prior to disposal into the natural
environment while in other sites they were disposed without any treatment. The leachates were collected by our team and
subjected to chemical characterization using Gas Chromatography-Mass Spectrometry GC/MS and toxicological assessment
using cytotoxicity and genotoxicity assays.
Findings: The study indicated significant high concentrations of Cadmium, Chromium, Copper, Aluminum, Manganese, Potassium,
Sodium Nickel and Calcium in comparison to a previous study undertaken on the municipal wastes in Lebanon and published data
fromworldwide landfills. The leachates also posed significant toxicological and genotoxicological risks as identified by the in vitro assays
conducted using human derived cells.
Conclusion & Significance: This study provided qualitative and quantitative
knowledge of the volatile and semi-volatile compounds in leachates from
numerous sites across Lebanon. Molecules related to cosmetics, medicines,
pharmaceuticals, agri- food repellents, plastics were reported in the study.
A significant toxic and genotoxic risks can be experimentally revealed by
the identification of DEHA, Phthalic acid, mono-(2-ethylhexyl) ester and
Tributylamine in untreated leachates dumped into the natural environment.
Recommendations are made for biological treatment of leachates prior to
disposal into the natural environment.
Recent Publications :
• Khalil C (2015) In vitro UVB induced cellular damage assessment using primary human skin derived cells. MOJ Toxicology. 1 (4): 20‐ 28.
• Y Siti Hajar, A Intasiri, C Winder and C Khalil (2013) In vitro cytotoxicity of mild steel and stainless steel welding fumes
using human‐derived cells. Health. 4 (2): 20‐36.
• Ghauri B, Manshaa M and Khalil C (2012) Characterization of cytotoxicity of airborne particulates from urban areas of
Lahore. Journal of Environmental Sciences 24 (11): 2028–2034.
• Soni B, Visavadiya N P, Dalwadi N, Madamwar D, Winder C and Khalil C (2010) Purified c‐phycoerythrin: Safety studies in
rats and protective role against permanganate mediated fibroblast‐DNA damage. Journal of Applied Toxicology. 30: 542–550.
Biography
Christian Khalil is a Professor of Environmental Toxicology. He is currently affiliated with Lebanese American University (LAU) in Lebanon. His other affiliations
include the Faculty of Built Environment and Institute of Environmental Studies, at the University of New South Wales (UNSW), School of Business at Australian
Catholic University (ACU) in Australia. He is also the Director of International Environmental Services (IES)- training and consulting organization based in Sydney,
Australia. He has a proven record of research by leading a number of research projects in the environmental toxicology arena. He enjoys a strong experience in
consulting government and industry on toxicological and pollution matters. He has numerous publications in his areas of interests like environmental toxicology,
management systems, environmental sustainability, work health and safety (WHS) and environmental pollution.
Christian Khalil et al., Toxicol Open Access 2017, 3:1 (Suppl)