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Volume 3, Issue 1 (Suppl) Toxicol Open Access
ISSN: 2476-2067 TYOA, an open access journal Toxicology Congress 2017
April 13-15, 2017
April 13-15, 2017 Dubai, UAE
8th World Congress on
Toxicology and Pharmacology
Effect of low-intensity 900 MHz frequency electromagnetic radiation on rat brain redox status and
cholinesterase activity linked to working memory
Samta Sharma and Sangeeta Shukla
Jiwaji University, India
Statement of the Problem: Behavioural impairments are the most empirical consequence of long-term mobile uses, but the
underlying causes are still poorly understood. Until now no study has been proposed to investigate the underlying causes of
behavioural effects induced by microwave exposure. Thus, the present study was undertaken to determine the influence of
microwave radiation on redox status, oxidative stress, cholinesterase activity, DNA damage and cognitive alterations in rat
brain.
Methodology & Theoretical Orientation: The study was carried out on 24 male Wistar rats, randomly divided into four
groups (n=6 in each group): Group I consisted of sham exposed (control) rats, group II, III and IV consisted of rats exposed to
microwave radiation (900 MHz) at different time duration 1h, 2h and 4h respectively (5 days/week). Rats were sacrificed and
decapitated to isolate.
Findings:Microwave exposure resulted ina time dependent significant increase inoxidative stressmarkers viz.malondialdehyde
(MDA) and catalase (CAT) in microwave exposed groups in comparison to sham exposed group (p<0.05). But, the levels of
superoxide dismutase (SOD) were found significantly decreased inmicrowave exposed groups (p<0.05). A significant alteration
in redox status was observed in microwave exposed animals (p<0.05). Furthermore, significant depletion in cholinesterase
activity and DNA damage was also observed in microwave exposed groups as compared to their corresponding values in sham
exposed group (p<0.05).
Results: In conclusion, the present study suggests that microwave radiation induces oxidative stress, depleted redox status,
DNA damage and reduces working memory in brain by exerting a time dependent effect.
Biography
Samta Sharma is a Research Associate in an ICMR funded project. She has completed her Doctorate in Life Sciences. She has published scientific paper and a
book, also has got awards in conferences.
Samta Sharma et al., Toxicol Open Access 2017, 3:1 (Suppl)