toxicology-congress-2017-scientifictracks-abstracts

20 / 33

Page 52
Notes:
conferenceseries.com
Volume 3, Issue 1 (Suppl) Toxicol Open Access
ISSN: 2476-2067 TYOA, an open access journal Toxicology Congress 2017
April 13-15, 2017
April 13-15, 2017 Dubai, UAE
8th World Congress on
Toxicology and Pharmacology
Protective effects of caffeic acid on Acrylamide induced toxicity in rats
Sadhana Shrivastava, Chhavi Uthra and Sangeeta Shukla
Jiwaji University, India
Statement of Problem: Studies concerning toxicity of Acrylamide and its metabolite - glicydamide showed neurotoxic and
genotoxic effect. Acrylamide (AA) is a synthetic chemical compound which is used in industry plastics, paints, cellulose-paper,
cosmetic industries and its forms in some starchy foods during high-temperature cooking. Caffeic acid is a hydroxycinnamic
acid found in barley grain and is an active antioxidant which scavenges free radicals. The present investigation was planned to
investigate the therapeutic effect by caffeic acid against AA.
Methodology &Theoretical Orientation: AAwas administered at the dose of 19.13 mg/kg, p.o. for 28 days to albino rats followed
by therapy with 20 mg/kg, p.o. of caffeic acid for 7 days.
Findings: Significant increase in serum albumin, bilirubin, triglyceride, cholesterol, SALP, LDH, GGT, ALAD, ALAS was
noted, as compared to the control group. Urea and creatinine was also
increased, which indicated renal damage. Activity of acetylcholisterase
and antioxidant defense system enzymes such as glutathione reductase
(GR), glutathione peroxidase (GPx) and glutathione-S-transferase
(GST) were decreased in all tissues significantly after AA administration.
Histopathological observation also supported biochemical studies as AA
caused degeneration in the hepatocytes, hypercellularity in glomeruli
and hypertrophy in epithelial cells and disorganization in the neurons.
Conclusion & Significance: This study has shown that caffeic acid
protects against AA toxicity.
Biography
Sadhana Shrivastava has completed her PhD and Post-doctoral studies from Jiwaji University. She is currently working as a Scientist in DHR funded project. She
has published more than 45 papers in reputed journals and books. She has been awarded many national awards and fellowships.
Sadhana Shrivastava et al., Toxicol Open Access 2017, 3:1 (Suppl)