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conferenceseries

.com

Volume 9, Issue 5 (Suppl)

J Bioequiv Availab, an open access journal

ISSN: 0975-0851

Pharmacy & Biopharma 2017

August 31-September 01, 2017 Philadelphia, USA

August 31-September 01, 2017 Philadelphia, USA

3

rd

International Conference on

Biopharmaceutics and Biologic Drugs

&

5

th

International Pharmacy Conference

Harmaline interaction with D2 signaling in tremor and attenuation of sensory-motor activity in mice

Xiping Zhan

Howard University, USA

E

ssential tremor is one of the most common neurological disorders characterized by uncontrollable shaking and tremors

throughout the body. Well known to affect adults, it can also affect children. Harmaline induced tremor is an established

animal model for human essential tremor, but its underlying mechanism and effects on mood behavior are still elusive. This

study aims to use pharmacological and behavioral methods to investigate the pharmacology in harmaline-induced tremor

and the auditory startle response. Mice tremors and auditory startle responses were recorded by the Kinder Startle Monitor

System. Harmaline (12.5 mg/kg) reliably induced tremor, and that can be attenuated by ethanol (1.5 mg/kg) and sulpiride

(20 mg/kg). In addition, it caused the startle response to decrease significantly. Prepulse inhibition and gap responses also

decreased upon harmaline injection and increased the following day, but not significantly from the controls. Supplemental

administration following recovery can significantly attenuate gap detection without affecting prepulse inhibition. Our data

confirms the frequency of the tremor was from 10-15 Hz, and the ethanol effect, which indicates validity as novel tremor assay.

We also found that harmaline attenuates the auditory startle reflex by causing the reflex and gap detection to be suppressed, but

did not affect prepulse inhibition significantly. These findings suggest harmaline not only specifically modulates sensory-motor

integration, but also the timing of gap detection. Our data provides additional information that D2 receptors are involved in

harmaline-induced tremor.

Biography

Xiping Zhan has his expertise in Neuropharmacology. His lab uses multiple interdisciplinary approaches to study neural circuits and underlying functional implications.

He applies behavior measures to evaluate the neuropharmacology of small molecular drugs on tinnitus, tremor or mood behavior, and uses patch clamping or single

unit

in vivo

recording to address the molecular mechanisms. In addition, he uses human iPS cell derived dopamine neurons to model pharmacology in human. He

has been focused on tinnitus and tremor for years in research and teaching.

xipingzhan@hotmail.com

Xiping Zhan, J Bioequiv Availab 2017, 9:5 (Suppl)

DOI: 10.4172/0975-0851-C1-031