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Volume 4, Issue 4 (Suppl) J Pharma Care Health Sys
ISSN: 2376-0419, JPCHS, an open access journal Pharma Middle East 2017
September 25-26, 2017
September 25-26, 2017 Dubai, UAE
12th Annual Pharma Middle East Congress
Development of nano drug delivery system to treat basal cell carcinoma
G N K Ganesh
JSS College of Pharmacy, India
Nano emulsions are the novel carriers which offer major enhancements in therapeutics through site specificity, their capacity
to escape frommulti-drug resistance and to reduce side effects due to its self-assembled nature that is inherently receptive
to its direct environment and the flexibility of the components which can be combined to result in structures with multiple
responsive functionalities. The aim of the study was to prepare nanoemulsion gel containing Imiquimod by spontaneous
emulsification method by using oleic acid as oil, Labrasol as a surfactant and PEG-600 as a co-surfactant which found to
be compatible by FT-IR. The optimized formulation after thermodynamic studies is subjected for various evaluations. The
particle/globule size of optimized formulation was found to be 127 nm with 29 mV zeta potential. The TEM analysis reveals
that droplets in the nanoemulsion appear dark and the droplet size was in agreement with the results obtained from droplet size
analysis using zetasizer. In vitro release study using franz-diffusion cells resulted in the cumulative release from nanoemulgel
and marketed cream at the end of 24 hours were 65.12±1.23 and 43.41±1.21, respectively and the flux calculation shows the
linear drug release of the formulation indicating a zero-order kinetics rather than marketed cream. Percentage hemolysis was
found to be less than 5% for formulation and marketed cream. In vitro cytotoxicity study using HaCat cell lines reveals the
IC50 values of the plain drug (IQ), prepared nanoemulgel and marketed cream to be 182.2 μg/ml, 260 μg/ml and 200 μg/ml,
respectively.
Biography
G N K Ganesh has completed his PhD from Jagadguru Sri Shivarathreeshwara University, Mysore. Presently he is working as a Professor in JSS College of
Pharmacy, India. He has published more than 30 papers in reputed journals and has been serving as an Editorial Board Member of 3 reputed journals. He has
presented many papers in both national and international conferences. He has more than 15 years of experience in both academic and research.
G N K Ganesh, J Pharma Care Health Sys 2017, 4:4 (Suppl)
DOI: 10.4172/2376-0419-C1-023