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Volume 4, Issue 4 (Suppl)
J Pharma Care Health Sys
ISSN: 2376-0419, JPCHS, an open access journal
Pharma Middle East 2017
September 25-26, 2017
September 25-26, 2017 Dubai, UAE
12
th
Annual Pharma Middle East Congress
Effects of herniarin on sepsis induced rats’ liver
Tuba Aydin
1
, Huseyin Serkan Erol
2
, Ahmet Cakir
3
, Serkan Yildirim
2
, Yavuz Selim Salam
2
and Mesut Halici
2
1
Agri Ibrahim Cecen University, Turkey
2
Ataturk University, Turkey
3
Kilis 7 Aralik University, Turkey
S
epsis development can result in death, through the passage of microorganisms into the blood entering the body and
spreading to all organ systems.
Artemisia dracunculus
L., tarragon, which is used in various parts of the world as spice,
has long been used in traditional therapy. Tarragon leaves have important coumarin content and contain high amounts of
herniarin (HRN). One of the most frequently used animal models in the study of sepsis is cecal ligation-puncture in rats’. In
the present study, effects of HRN, isolated from tarragon was investigated on sepsis induced rats’ liver tissues. Therefore, 40
male rats were divided into 4 groups as Sham, Control, HRN-150 and HRN-300. HRN was orally given (at doses of 150 and
300 mg/kg) and then rats’ cecums were ligatured and perforated by a cannule. After 24 hours after administration of HRN,
rats were euthanized under high dose anesthesia. Both histopathologic and biochemical examinations were performed in the
liver tissues of sepsis induced rats. Lipid peroxidation (LPO) and glutathione (GSH) levels, as well as superoxide dismutase
(SOD) and catalase (CAT) activities were measured as biochemical parameters. In the control group, as compared with sham
group, both LPO level and CAT activity increased significantly (p<0.05), in contrast to the decreased amouts of GSH and SOD
activity. In the HRN groups, the LPO and CAT was significantly decreased and also decreased amouts of GSH and SOD activity
was increased dose dependently. According to the results histopathologically, damage findings are decreased as parallel to the
biochemical data in a dose-dependent manner. As conclusion HRN dose-dependently decreased sepsis resultant liver damage
(p <0.05).
Biography
Tuba Aydin has completed her PhD from Ataturk University in 2012. She is currently working as an Assistant Professor in the Faculty of Pharmacy at the Agri
Ibrahim Cecen University, Turkey, where she has been a Faculty Member since 2013. She has expertise in isolation and characterization of phytochemicals from
natural products.
aydintuba25@gmail.comTuba Aydin et al., J Pharma Care Health Sys 2017, 4:4 (Suppl)
DOI: 10.4172/2376-0419-C1-023