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.com
Volume 4, Issue 4 (Suppl)
J Pharma Care Health Sys
ISSN: 2376-0419, JPCHS, an open access journal
Pharma Middle East 2017
September 25-26, 2017
September 25-26, 2017 Dubai, UAE
12
th
Annual Pharma Middle East Congress
Development of gastro-retentive drug delivery systems based on N-isopropyl acrylamide hydrogels
Rubab Zohra
Forman Christian College, Pakistan
I
t was planned to synthesize dual-responsive hydrogels from N-isopropyl acrylamide (NiPAAm), acrylic acid (AA) and
methacrylate (MA). Hydrogels were prepared by free radical copolymerization using ethyl alcohol as a solvent, a redox
initiator, benzoyl peroxide (BPO) and ethylene glycol dimethacrylate (EGDMA) and diethylene glycol dimethacrylate
(DEGDMA) as cross-linkers. The network parameters like polymer mesh size (ξ) (23.78 to 820 Å), molecular weight between
the cross-links (M
c
) (970-356096 gmol-1) and crosslink density (q), (0.0928 to 0.00025) were calculated at various pH using the
Flory-Rehner theory. Hydrogels exhibited the non-Fickian diffusion mechanism. FTIR spectral analysis and (TGA/DSC) were
carried out to characterize the systems and new LCST was found to be increased. Tramadol HCl was used as the model drug to
investigate the drug loading and unloading behavior of these gels. It was concluded that these systems exhibited a sharp change
in their media sorption capacity and mesh size of the networks with the change in the pH and temperature of the swelling
media, proposing their strong candidature for being used as oral drug delivery systems. The results favored the idea to apply
these hydrogels to use as targeted drug delivery systems for the proximal part of the gastro-intestinal tract.
Biography
Rubab Zohra is working as an Associate Professor at Department of Chemistry in Forman Christian College (A Chartered University), Lahore, Pakistan.
rubabzohra@gmail.comRubab Zohra, J Pharma Care Health Sys 2017, 4:4 (Suppl)
DOI: 10.4172/2376-0419-C1-023