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Volume 4, Issue 4 (Suppl) J Pharma Care Health Sys
ISSN: 2376-0419, JPCHS, an open access journal Pharma Middle East 2017
September 25-26, 2017
September 25-26, 2017 Dubai, UAE
12th Annual Pharma Middle East Congress
Formulation and evaluation of Gastro-Retentive Floating Matrix Tablets (GRFMTs) of Metformin
using Grewia mollis gum
Collins Ovenseri Airemwen
University of Benin, Nigeria
Grewia polysaccharide gumwas obtained from the inner stem bark of the edible plant Grewia mollis Juss, (Family: Tiliaceae).
Granules were prepared by wet granulation technique using the extracted natural gums at varying concentrations (2, 4, 6
and 8% w/w). Sodium bicarbonate (30%) and tartaric acid (5%) were incorporated as the gas generating agents. All granules
were evaluated for micromeritic properties. Granules were compressed at an optimized compression pressure of 35 arbitrary
units on the load scale using a single punch tableting machine. Tablets were evaluated for hardness, friability, floating lag time,
in vitro buoyancy test and drug release profiles. Compatibility test of the excipients with the API (metformin) was also done
using FTIR. Results revealed that all formulated GRFM granules were free flowing with angle of repose and Carr’s index ≤31o
and ≤14% respectively. The floating lag time for GRFM tablets formulated with Grewia mollis was ≤850 s. The in vitro buoyancy
test of GRFM tablets formulations using the natural gum alone (i.e., without the incorporation of Eudragit® RL100) were <12
hours while those formulations with the incorporation of Eudragit® RL100 were >12 hours. There was a significant difference
in tablet hardness with increase in binder concentration (p<0.05). The percentage maximum release (m∞) and time to attain
this (t∞) for all GRFMTs were ≥87% and ≥4 hours, respectively. All the formulations fitted well into Higuchi model release
kinetics. Release exponent (n) for all the formulations have their exponent values >0.45, hence their release mechanism was by
non-Fickian diffusion. GRFM tablets of metformin have been developed for the first time using Grewia mollis gum which can
sustain drug formulation for up to 10 hours and improve the bioavailability of drugs with narrow absorption window in the
upper part of the GIT. Batch GM5 showed a better sustained release profile which can be taken as the optimized formulation.
Biography
Collins Ovenseri Airemwen has received his Doctor of Pharmacy (PharmD) degree from the University of Benin, Benin City, Nigeria and Master of Philosophy
degree in Pharmaceutics and Pharmaceutical Technology from the same university. He is currently pursuing his PhD and has published more than 8 papers. His
research focuses on controlled drug delivery system.
Collins Ovenseri Airemwen, J Pharma Care Health Sys 2017, 4:4 (Suppl)
DOI: 10.4172/2376-0419-C1-023