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19th International Conference on
Obesity, Healthcare - Nutrition & Fitness
March 18 - 19, 2019 | New York, USA
Dietary modification
with high salt
attenuates obesity and
hyperlipidemia in high
fat induced obese mice
Mohammad Salim Hossain
Noakhali Science and Technology
University, Bangladesh
T he prevalence of obesity
is an alarming condition
for mortality and morbidity
leading to other lifestyle-
related diseases worldwide.
Finding out the new way
to combat obesity is the
most warrant. The aim of
the present study was to
investigate the effect of a
modified diet with high-salt
(4% NaCl) on fat deposition in
high-fat diet induced obese
mice. Forty healthy Swiss
Albino mice (Sex: Female) were
taken and divided equally into
two groups named as a non-
obese group and obese group.
In the case of a non-obese
group, mice were fed a normal
diet, normal diet along with
high-salt, high-fat diet, and
high-fat diet along with high-
salt for 6 weeks. On another
hand, to induce obesity, mice
were fed high-fat for 2weeks
and then treated with high-
fat diet along with high-salt,
normal diet, normal diet along
with high-salt again for 6weeks.
The effects of these treatments
on body weight, feed intake,
Lee index, organs weight and
levels of serum triglycerides
(TGs), total cholesterol (TC),
high density lipoprotein-
cholesterol (HDL-C), low
density lipoprotein-cholesterol
(LDL-C), SGOT and SGPT,
and atherogenic index of
plasma (AIP) were analysed.
In case of non-obese group,
treatment with high-fat diet
along with high-salt showed
a significant decrease in body
weight (p<0.05), organs weight
(liver, heart, and abdominal
fat) (p<0.05), serum TG, TC,
LDL-C (p<0.05) levels, AIP
(p<0.05) value and SGOT and
SGPT levels (p≤0.05) whereas
significant elevation was
noticed in HDL-C (p<0.05)
level compared to the HFD
group. Furthermore, in case
of obese group treatment
with high-fat diet along with
high-salt and normal diet
along with high-salt showed
a significant declination in
body weight (p<0.05), Lee
index (p<0.05), organs weight
(liver, heart, and abdominal
fat) (p<0.05), serum TG, TC,
LDL-C (p<0.01) levels, AIP
(p<0.01), SGOT and SGPT levels
(p<0.05) whereas significant
elevation was noticed in HDL-C
(p<0.01) level compared to
the Obese control group.
From the observations of the
study performed, it could be
predicted that high salt (4%
NaCl) diet has an inhibitory
action on fat absorption which
may be effective to attenuate
the obesity and obesity-related
parameters.
JOURNAL OF OBESITY &WEIGHT LOSS THERAPY 2019, VOLUME: 4 | DOI: 10.4172/2165-7904-C2-094 ACCEPTED ABSTRACTS