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Volume 8
Journal of Nutrition & Food Sciences
ISSN: 2155-9600
Nutri-Food Chemistry
&
Euro Obesity 2018
September 13-15, 2018
JOINT EVENT
September 13-15, 2018 | London, UK
14
th
Euro
Obesity and Endocrinology Congress
&
17
th
World Congress on
Nutrition and Food Chemistry
Effects of dietary phytochemicals on healthy ageing in a hormetic stress response manner
Ceren Gezer
Eastern Mediterranean University, Turkey
H
ormesis is defined as any circumstance in which chemical and environmental factors give beneficial effect to the cells in
an organism at low doses while causing harm for them at high doses. The stress responses observed in mammalian cells
can be classified as heat shock response, unfolded protein response, autophagic response, DNA damage response, antioxidant
response and sirtuin response at the intracellular and molecular levels. Factors which strengthen the hemodynamic structure
causing low level molecular damage and activating one or several stress response pathways are called hormetins. Hormetins
can be categorized as: physical hormetins, physiological hormesis, biological and nutritional hormetins. Nutritional hormetins
are an interesting, comprehensive research topic because of their effects on health and life span. Dietary phytochemicals are
potential nutritional hormetins with their low-level stress inducing effects. Resveratrol, curcumin, capsaicin, epicatechin,
isothiocyanates, ferulic acid and certain vitamin minerals can form heat shock response, unfolded protein response, auto
phagic response, DNA damage response, antioxidant response and sirtuin response causing the stimulation of kinases and
transcription factors. Studies generally have shown that these phytochemicals are related to nuclear factor erythroid 2 (Nrf-2)
and sirtuin pathway, heat shock response activation and nuclear factor kappa-B (NF-κB) down regulation. This study aims to
explain stress response effect mechanisms of the dietary phytochemicals, which show the property of nutritional hormetin as
important components that affect the delay of age related diseases, healthy aging and life span.
ceren.gezer@emu.edu.trJ Nutr Food Sci 2018, Volume 8
DOI: 10.4172/2155-9600-C7-072