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conferenceseries
.com
Volume 8
Journal of Nutrition & Food Sciences
ISSN: 2155-9600
Nutri-Food Chemistry
&
Euro Obesity 2018
September 13-15, 2018
JOINT EVENT
September 13-15, 2018 | London, UK
14
th
Euro
Obesity and Endocrinology Congress
&
17
th
World Congress on
Nutrition and Food Chemistry
Effect of a moderate-intensity continuous training program and cognitive behavioral psychotherapy
over the endothelial dysfunction genes expressions in overweight and obesity children
Gabriela Y C Moreno
Instituto Politécnico Nacional, Mexico
Background:
The worldwide obesity epidemic has stimulated interest to find early interventions that could be implemented in
childhood and adolescence, with consideration of biomarkers that are potentially predictive of cardiometabolic complications
present at later ages. Interventions such as moderate-intensity continue training program (MCIT) and cognitive behavioral
therapy (CBT) are the mainstay of treatment for this condition. Such interventions may lead to changes at the molecular level
in the expression of genes involved in endothelial dysfunction such as PRMT1, DDAH1 and ADMA.
Objective:
This study evaluated the effect of moderate-intensity continues training program and cognitive-behavioral program
over gene expression associated with endothelial dysfunction in children aged 6-12 years who were overweight or obese.
Methods:
We recruited 26 patients with overweight and obesity diagnosed according to the CDC tables between 6-12 years, of
which peripheral blood was obtained. One group had the MCIT intervention (n = 13), and the other group with MCIT + CBT
intervention (13), both groups were treated for 12 weeks. Anthropometric and biochemical variables were measured, gene
expression was quantified by the real-time PCR technique.
Results:
Both groups had a decrease in the anthropometric parameters such as BMI, waist, WHtR (p <0.05), the group of
MCIT + CBT also decreased the WHR and triglycerides (p <0.05). Regarding gene expression, mRNA levels of PRMT1,
DDAH1 behaved differently in each group since the group of MCIT + CBT had an overexpression of DDAH1 and ADMA in
contrast to the group of CBT that lowered their expression significantly (p = 0.001, p = 0.039 respectively).
Conclusions:
The interventionofMCITrepresents aneffective intervention todecrease endothelial damage and cardiometabolic
complications, by increasing the levels of expression of DDAH1 and having a downward trend of the PRMT1 gene both are
ADMA regulators, that is a potentially marker of cardiovascular risk.
medic_gaby@live.com.mxJ Nutr Food Sci 2018, Volume 8
DOI: 10.4172/2155-9600-C7-072