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Notes:
Volume 7, Issue 3 (Suppl)
J Nutr Disorders Ther, an open access journal
ISSN: 2161-0509
Page 68
JOINT EVENT
&
July 27-29, 2017 Rome, Italy
Advances in Natural Medicines Nutraceuticals & Neurocognition
14
th
International Conference on Clinical Nutrition
13
th
International Congress on
Spirulina maxima
extract protects against TMT-induced neuronal damage in HT-22 and SH-SY5Y
cells
Boo-Yong Lee, Eun-Jeong Koh
and
Young-Jin Seo
CHA University, South Korea
P
rogressive neurodegeneration causes cognitive disease such as Alzheimer’s disease (AD) due to neuronal death and
dysfunction of neuronal system network.
Spirulina maxima
is a microalga and contains protein, flavonoids, polyphenols
and other essential nutrients. Recently, many studies have been demonstrated that
Spirulina maxima
has anti-diabetes, anti-
cancer and anti-inflammatory effects. However, the effects of
Spirulina maxima
extract on cognitive disorders are not studied
in detail. And so we investigate whether
Spirulina maxima
extract has neuroprotective effect in TMT-induced neuronal
damage in neuronal cells. Trimethyltin (TMT) is a neurotoxic compound which causes neuronal cell death and is used as
model of cognitive disorders. Our results showed that
Spirulina maxima
extract increases cell viability with TMT treatment
by measuring MTT assay in HT-22 and SH-SY5Y cells.
Spirulina maxima
extract reduced the cleavage of poly-ADP ribose
polymerase (PARP). ROS production was repressed by down regulating nuclear factor erythroid 2-related factor 2 (Nrf2),
and heme oxygenase 1 (HO-1) which is related with the oxidative stress. Recently, other publications also have been showed
that Nrf2/HO-1 signaling pathways is associated with TMT-induced neuronal disorders. Furthermore,
Spirulina maxima
extract accelerated the neuroprotective related proteins such as brain-derived neuro-trophic factor (BDNF), and cyclic AMP
responsive element binding protein (CREB) in HT-22 and SH-SY5Y cells. Conclusively in our study
Spirulina maxima
extract
has neuroprotective effects against TMT-induced cognitive disorders in HT-22 and SH-SY5Y cells.
Biography
Boo-Yong Lee has his expertise in research and passion in improving the health and wellbeing. His open and contextual evaluation model based on responsive
constructivists creates new pathways for development of functional foods and nutrigenomics. He has built this model after years of experience in Research,
Evaluation, Teaching and Administration in education institutions.
bylee@cha.ac.krBoo-Yong Lee et al., J Nutr Disorders Ther 2017, 7:3(Suppl)
DOI: 10.4172/2161-0509-C1-007